Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation

Active, not recruiting

• Conditions: Kidney Transplantation; Haemodialysis; Pulmonary Hypertension
• Interventions: Diagnostic Test: exercise echocardiography

• Registration Number: NCT04842591
• Lead Sponsor: Medical University of Graz

Brief Summary

The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-23
• Study First Submitted: 2021-04-08
• Study First Submitted QC: 2021-04-08
• Study First Posted: 2021-04-13
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-23
• Last Update Posted: 2025-04-27
• Primary Completion: 2027-12-31
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age: ≥ 18 years
• patients listed for first kidney transplantation at the Clinical Division of Nephrology

Exclusion Criteria

• Age < 18 years
• combined organ transplantations (heart-kidney, pancreas-kidney etc.)
• patients with prior kidney transplantation
• high calcium score on cardiac-CT (> 160 Agatston Score)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
kidney transplant candidates	exercise echocardiography	Patients listed for first kidney transplantation

Primary Outcome Measures

Name	Time	Method
Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope	Baseline and 1 year after kidney transplantation	Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope (calculated as the difference of maximal and resting SPAP divided by the difference of maximal and resting CO) before versus one year after kidney transplantation assessed by exercise echocardiography

Secondary Outcome Measures

Name	Time	Method
Change in mean pulmonary arterial pressure during exercise before versus one year after kidney transplantation	Baseline and 1 year after kidney transplantation
Change in pulmonary vascular resistance at rest before versus one year after kidney transplantation	Baseline and 1 year after kidney transplantation
Change in systolic pulmonary arterial pressure at rest before versus one year after kidney transplantation assessed by (exercise) echocardiography	Baseline and 1 year after kidney transplantation
Change in pulmonary vascular resistance during exercise before versus one year after kidney transplantation	Baseline and 1 year after kidney transplantation
Change in systolic pulmonary arterial pressure at 25 Watts before versus one year after kidney transplantation assessed by (exercise) echocardiography	Baseline and 1 year after kidney transplantation
Change in mean pulmonary arterial pressure at rest before versus one year after kidney transplantation	Baseline and 1 year after kidney transplantation
Change in cardiac output during exercise before versus one year after kidney transplantation	Baseline and 1 year after kidney transplantation
Change in pulmonary arterial wedge pressure during exercise before versus one year after kidney transplantation	Baseline and 1 year after kidney transplantation
Change in pulmonary arterial wedge pressure at rest before versus one year after kidney transplantation	Baseline and 1 year after kidney transplantation
Change in cardiac output at rest before versus one year after kidney transplantation	Baseline and 1 year after kidney transplantation

Trial Locations

Locations (1)

Medical University of Graz, Department of Internal Medicine, Division of Pulmonology; 🇦🇹 Graz, Austria