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Clinical Trials/NCT06640023
NCT06640023
Enrolling By Invitation
Not Applicable

The Study in Outpatient Medicine Using Nudges to Improve Sleep: The SOMNUS Trial

University of Southern California2 sites in 1 country444 target enrollmentDecember 20, 2024

Overview

Phase
Not Applicable
Intervention
Control
Conditions
Inappropriate Prescribing
Sponsor
University of Southern California
Enrollment
444
Locations
2
Primary Endpoint
Z-drug pill count
Status
Enrolling By Invitation
Last Updated
5 days ago

Overview

Brief Summary

The goal of this clinical trial is to learn if electronic health record (EHR) nudges (changes to the EHR that do not restrict freedom of choice or alter incentives) can reduce Z-drug prescribing in primary care clinics for patients with insomnia. The main questions it aims to answer are:

  1. Can Z-drug prescribing be reduced by setting the dispense quantity default of new Z-drug orders in the EHR to 10 pills with 0 refills?
  2. Can Z-drug prescribing be reduced by an EHR alert that suggests clinicians remove a Z-drug and/or add an evidence-based behavioral treatment for insomnia, followed by a request to justify their reasoning if the suggestion is not followed?
  3. Does combining these two nudges reduce Z-drug prescribing?

Researchers will compare each nudge individually and in combination to an guideline education control group to see if each nudge (separately and in combination) can reduce Z-drug prescribing.

Clinician-participants will:

  1. Complete an introductory educational module about treating insomnia and relevant EHR changes.
  2. Complete their routine patient visits.
  3. Either experience EHR changes when prescribing Z-drugs, including a Z-drug dispense quantity default of 10 pills for new orders, a prompt to remove or justify Z-drug orders, both, or neither.
Registry
clinicaltrials.gov
Start Date
December 20, 2024
End Date
June 1, 2027
Last Updated
5 days ago
Study Type
Interventional
Study Design
Factorial
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Jason Doctor

Professor

University of Southern California

Eligibility Criteria

Inclusion Criteria

  • Outpatient primary care clinician at Northwestern Medicine

Exclusion Criteria

  • Clinician participated in pilot study
  • Clinician-investigator for this trial
  • Visit involves patient with ICD-10 F31.X diagnosis code (bipolar disorder) present in the last year or on active problem list

Arms & Interventions

Control

Clinicians randomized to this arm receive guideline education prior to the trial.

Z-drug Default Quantity

Clinicians randomized to this arm receive guideline education + 10 pill quantity defaults.

Intervention: Z-drug Default Quantity

Redirection + Accountable Justification

Clinicians randomized to this arm receive guideline education + alerts requiring justification of orders discordant with guidelines. Justifications are entered in the patient's medical record, and can be viewed by other clinicians.

Intervention: Redirection + Accountable Justification

Combined

Clinicians randomized to this arm receive guideline education + 10 pill quantity defaults + alerts requiring justification of orders discordant with guidelines. Justifications are entered in the patient's medical record, and can be viewed by other clinicians

Intervention: Z-drug Default Quantity

Combined

Clinicians randomized to this arm receive guideline education + 10 pill quantity defaults + alerts requiring justification of orders discordant with guidelines. Justifications are entered in the patient's medical record, and can be viewed by other clinicians

Intervention: Redirection + Accountable Justification

Outcomes

Primary Outcomes

Z-drug pill count

Time Frame: 36 months

Dose-equivalent Z-drug pill count prescribed at eligible encounters by clinicians from 18 months prior to the intervention start to 18 months after the intervention start.

Secondary Outcomes

  • Z-drug pill count among short-term users(36 months)
  • Z-drug pill count among long-term users(36 months)
  • CBT-I referrals(18 months)
  • CBT-I referrals among short-term users(18 months)
  • CBT-I referrals among long-term users(18 months)
  • Monthly Z-drug pill count(36 months)
  • Benzodiazepine pill count(36 months)
  • Z-drug guideline discordant duration(36 months)

Study Sites (2)

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