Postoperative Nausea and Vomiting: Ramosetron Plus Aprepitant vs Palonosetron Plus Aprepitant
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 88
- 主要终点
- The Incidence of Postoperative Nausea and Vomiting
研究概览
简要总结
The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.
详细描述
The purpose of this study was to compare the antiemetic efficacy of aprepitant plus palonosetron versus aprepitant plus ramosetron in high risk patients undergoing laparoscopic cholecystectomy.
Study is performed during 24 hours after surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Non smoking, female patients, scheduled for laparoscopic cholecystectomy
排除标准
- •Patients with gastrointestinal disorder,
- •Patients with allergies to any study medication,
- •Patients who had received any sedatives, opioid, steroid or antiemetics within 24 h before surgery
研究组 & 干预措施
aprepitant plus palonosetron
aprepitant 80 mg palonosetron 0.075 mg
干预措施: aprepitant (Drug)
aprepitant plus palonosetron
aprepitant 80 mg palonosetron 0.075 mg
干预措施: palonosetron (Drug)
aprepitant plus ramosetron
aprepitant 80 mg ramosetron 0.3 mg
干预措施: aprepitant (Drug)
aprepitant plus ramosetron
aprepitant 80 mg ramosetron 0.3 mg
干预措施: Ramosetron (Drug)
结局指标
主要结局
The Incidence of Postoperative Nausea and Vomiting
时间窗: 24 hours
The incidence of postoperative nausea and vomiting during 24 hours postoperatively
次要结局
未报告次要终点
研究者
Younghoon Jeon
Professor
Kyungpook National University Hospital