Transcranial Magnetic Stimulation and Bulimic Craving

Not Applicable

Completed

• Conditions: Bulimia
• Interventions: Device: rTMS Placebo (SHAM); Device: rTMS session

• Registration Number: NCT02547246
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Bulimic patients suffering from binge eating or "craving" a pressing need to eat, with a sense of unease and anxiety, relieved by food intake. The phenomenon of craving bulimia may be considered appropriately by using paradigms developed in the framework of embodied cognition theories.

In bulimic, a study with 20 bulimic patients proved an automatic attraction (unconscious) for food in these patients, as measured by reaction time.

Moreover, a therapeutic explored in bulimia (particularly on reducing craving), is repeated transcranial magnetic stimulation (rTMS). Studies have shown that a single session of rTMS to the dorsolateral prefrontal cortex left (DLPFC) reduces significantly the food craving among bulimics, 24 hours after stimulation. But the therapeutic efficacy of TMS on bulimia to more than 24 hours has not yet been demonstrated, and the psycho-cognitive underlying mechanisms have not yet been explored.

Detailed Description

The exams / treatments of the study include:

* a 20 minute session of rTMS at a frequency of 10 Hz.

* cognitive testing and attention, which will be made on the computer before and 24 hours after the session of rTMS.

Cognitive test consist in , on a computer screen:

* Is first displayed, food and non-food words. The patient must pull a lever to it if the letter A is present in the word and push the lever if the letter A is missing the word.

* Then presents a series of food and non-food words. The patient must pull a lever to it if it deems that the word has a positive meaning and push the lever if it determines that the word has a negative meaning

Study Timeline

• Study Start: 2012-01
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Study First Submitted: 2015-09-09
• Study First Submitted QC: 2015-09-09
• Study First Posted: 2015-09-11
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-22
• Last Update Posted: 2016-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• right-handed patient
• Patients without psychotropic treatment or treatment with a stable and unchanged for over a month.
• Normal BMI

Exclusion Criteria

• Previous history of seizures or epilepsy.
• Participants with a somatic problem restricted movement or an uncorrected visual acuity problem.
• History of head trauma, neurological disease or unstabilized serious physical illness.
• Major Depressive Episode at the time of the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
rTMS placebo (SHAM) session	rTMS Placebo (SHAM)	Patients will have a 20 minute session of placebo rTMS
rTMS session	rTMS session	Patients will have a 20 minute session of rTMS at a frequency of 10 Hz.

Primary Outcome Measures

Name	Time	Method
Motor response time	24h after rTMS session	time taken to pull or push the lever in cognitive tests (composite measure)

Trial Locations

Locations (1)

CHU de SAINT-ETIENNE; 🇫🇷 Saint-etienne, France