A COMPARATIVE EVALUATION OF THREE DOSES OF DEXMEDETOMIDINE AS AN ADJUVANT TO BUPIVACAINE ON DIFFERENTIAL ANALGESIA IN ADULT PATIENTS UNDERGOING ELECTIVE INFRAUMBLICAL SURGERIES UNDER SUBARACHNOID BLOCK
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To study and compare duration of differential analgesia in patients undergoing elective Infra
研究概览
简要总结
The study is an interventional comparative study to find out and compare duration of differential analgesia, using three doses of intrathecal Dexmedetomidine as an adjuvant to Bupivacaine(H) 0.5% in adult patients undergoing elective infra umblical surgeries in subarachnoid block.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Adult patients of age 18-65y, of either gender, belonging to American Society of Anaesthesiologists (ASA) physical status I and II, scheduled for elective Infra-umbilical surgeries under subarachnoid block.
排除标准
- •Patients with contraindication of Subarachnoid block.
- •Patients having hyper-sensitivity to drugs used in the study.
- •Patients with significant co-morbid conditions.
- •Patients with history of analgesic abuse/drug abuse/ cognitive impairment/ psychiatric illness.
结局指标
主要结局
To study and compare duration of differential analgesia in patients undergoing elective Infra
时间窗: Time from onset of Bromage score 0 to requirement of first rescue analgesic.
Umbilical surgeries using three different doses of Intrathecal Dexmedetomidine (2.5μg, 5μg,
时间窗: Time from onset of Bromage score 0 to requirement of first rescue analgesic.
10μg) as an adjuvant to Bupivacaine(H) 0.5% in subarachnoid block.
时间窗: Time from onset of Bromage score 0 to requirement of first rescue analgesic.
次要结局
- To compare total duration of analgesia, onset of sensory and motor blockade, intraoperative hemodynamic parameters and sedation, cumulative analgesic use in 24-hour period postoperatively.(Intraoperative and Post operative till 24 hours)