Association of Intestinal Microbiota and the Onset of Perianal Abscess Based on 16S RDNA Amplicon Sequencing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Observation group: the structure and changes of rectal flora before and after treatment
研究概览
简要总结
The goal of this observational study is tolearn the association of gut microflora with the onset of perianal abscesses. The main questions it aims to answer are:
Question 1: To understand the structure of rectal microbial community composition and its relationship with pathogenic bacteria in patients with perianal abscess.
Question 2: Understand the structure of rectal microbial community composition in healthy people.
Participants will be collected with rectal secretions and stool specimens.In addition, patients with perianal abscess should also collect pus samples.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Observation group: ① Age between 18-60 years, local resident of Xi'an; ② met the diagnostic criteria for perianal abscess and underwent surgical treatment in our hospital; ③ did not use antibiotics before treatment; ④ himself and his family members were willing to participate in this study and signed informed consent.
- •Control group: ① Age between 18-60 years, permanent residents in Xi'an; ② had no serious chronic disease, no abnormality in physical examination in the last 1 week; ③ did not use drugs that may affect intestinal flora in the last one month; ④ himself and his family members are willing to participate in the study and sign the informed consent.
排除标准
- •Failing to retain the specimens as required
结局指标
主要结局
Observation group: the structure and changes of rectal flora before and after treatment
时间窗: Two months
Analysis of the intestinal microflora based on 16S rDNA amplicon sequencing
Control group: the structure and changes of rectal flora in healthy population
时间窗: Two months
Analysis of the intestinal microflora based on 16S rDNA amplicon sequencing
次要结局
未报告次要终点