Effect of Chlorhexidine Bathing on Prevention of Hospital-Acquired Infections in Patients After Surgery in ICU: A Prospective, Single-Center, Single-Blind, Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 247
- 试验地点
- 1
- 主要终点
- Incidence of hospital-acquired infections
研究概览
简要总结
Hospital-acquired infections (HAI) have been shown to increase length of hospital stay and mortality. Infections acquired during a hospital stay have been shown to be preventable. The skin of patients is considered a major reservoir for pathogens associated with hospital-acquired infections, and has been suggested as a potential target for interventions to reduce bacterial burden and subsequent risk of infection. The use of daily Chlorhexidine (CHG) bathing in intensive care patients has been advocated to reduce many of the infections in critically ill patients. However, the effectiveness of CHG bathing to reduce ICU infections has varied considerably among published trials, making the effectiveness of CHG bathing in ICU patients uncertain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adults (≥ 18-years old)
- •anticipated SICU stay for 48 hours or more
- •APACHE II >15
排除标准
- •Braden Scale for Predicting Pressure Sore Risk score more than 9 (highest risk)
- •pregnancy
- •skin irritation
- •chlorhexidine allergy
- •SICU stay of more than 48 hours prior to screening
结局指标
主要结局
Incidence of hospital-acquired infections
时间窗: throughout study completion, an average of 7 days
Including bloodstream infections (BSI), central line-associated BSI (CLABSI), ventilator-associated pneumonia (VAP) and catheter-associated urinary tract infection (CAUTI).
次要结局
- Multidrug-resistant bacterial colonization free time(throughout study completion, an average of 7 days)