ASSIST: A Surveillance Study of Illicit Substance Toxicity - Clinical Characterisation and Toxicological Analysis of Emergency Department Presentations in Glasgow
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Proportion of full data sets and toxicology analysis for all patient attending the ED due to acute illicit drug toxicity
研究概览
简要总结
There is a drug-related death crisis in Scotland. This study aims to collaborate with Public Health Scotland in order to assess the feasibility of introducing a surveillance system to the Emergency Department to highlight illicit drug-related attendances. This will utilise both clinical data and toxiclogical analysis of anonymised samples. The data will inform of prevalence, trend data and utcome of ED patients attending with acute illict drug toxicity.
详细描述
The purpose of this research is to establish the introduction of a robust toxicology surveillance system in the Emergency Department (ED) in order to inform public health interests. The study will explore the feasibility of reporting characteristics and causative agents of patients attending hospital as an emergency due illicit substance use. The term illicit substance used during this study encompasses any substance which is not prescribed to the individual and is a controlled drug as per the Misuse of Drugs act 1971 and Misuse of Drugs Regulations 2001.
The study will look at standard care clinical data from all individuals attending the Emergency Department due to acute illicit drug toxicity. Surplus blood samples will be anonymised and analysed for toxicological profiling.
The study will allow identification of emerging drug trends and will be shared contemporaneously with Public Health Scotland and inform the Scottish Government of current incidences to inform public health measures to tackle the drugs death crisis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient attending QEUH ED directly relating to acute illicit drug use
- •Patients with reported acute illicit drug use toxicity who are unwell before they are seen in the Emergency Department but appear well in the ED should also be included
排除标准
- •Condition more likely due to cause other than acute illicit drug use
- •Condition due to withdrawal of drugs / alcohol
- •Condition primarily related to alcohol use and no evidence of acute illicit drug use
- •Attendance is due to complication of previous drug use - i.e., BBV / infected injection site (without acute drug toxicity)
结局指标
主要结局
Proportion of full data sets and toxicology analysis for all patient attending the ED due to acute illicit drug toxicity
时间窗: 1 year
Objective: Assess the feasibility of prospective surveillance of Emergency Department presentations relating to acute illicit drug toxicity Outcome measure: Proportion of full data sets and toxicology analysis for all patient attending the ED due to acute illicit drug toxicity
次要结局
- Production of automated pre-defined data capture, recording and auditing for the routine processing of drug related ED presentations that includes toxicological information(1 year)
- Proportion of patients who fit stage 2 criteria with biological sample mass spectrometry toxicology analysis(1 year)
- Proportion of illicit drug reported to have been taken and proportion of clinician presumed drug taken accurately matching toxicology analysis(1 year)
- Share learning and data with Scottish Government, PHS and other NHS boards to inform national scale up(1 year)
- Production of frequency and trend data to deliver to Public Health Scotland(1 year)
- Clinical phenotyping of patients attending due to acute illicit drug toxicity compared to reported / presumed drug taken(1 year)