Multi Donor Mismatched Stem Cell Transplantation (MDT)
Phase 1
- Conditions
- Graft-Versus-Host Disease
- Interventions
- Procedure: Multi donor stem cell transplantation
- Registration Number
- NCT00716690
- Lead Sponsor
- Hadassah Medical Organization
- Brief Summary
The proposed research focuses on the development of innovative protocol of mismatched stem cell transplantation with combined 2 different haplo stem cell transplantation (SCT) donors which are mismatched to the recipient (and preferably to each other), in a patient in need for SCT, lacking an HLA match related or an unrelated donor. This innovative protocol named multi donor stem cell transplantation (MDT) is designed to facilitate engraftment even when reduced intensity conditioning or a low cell dose are used, improve the graft vs. leukemia (GVL) effect and enhance immune reconstitution (using quantitative and qualitative parameters).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description treatment Multi donor stem cell transplantation -
- Primary Outcome Measures
Name Time Method Day of neutrophil engraftment 30d Day of platelet engraftment>20x10(9)L 30 Acute GVHD occurrence>2 100d Disease free survival 100d
- Secondary Outcome Measures
Name Time Method Transplant related toxicity 100d Immune reconstitution 100d Day of platelet engraftment>50x10(9)/L 30d Time of acute GVHD 100d GVHD grade 100d Overall survival 100 days Infections incidence 100d transplant-related mortality 100d
Trial Locations
- Locations (1)
Hadassah Medical Organization
🇮🇱Jerusalem, Israel