High-Frequency Repetitive Transcranial Magnetic Stimulation Assists In Smoking Cessation
- Conditions
- Heavy Smoking
- Interventions
- Device: Transcranial Magnetic Stimulation 10HzDevice: Magnetic stimulation using a special sham coil
- Registration Number
- NCT00284219
- Lead Sponsor
- Sheba Medical Center
- Brief Summary
Cigarette smoking is a major public health problem causing significant morbidity and mortality. Yet, smoking cessation therapies are often ineffective at helping smokers break their addiction.
The mesolimbic dopaminergic reward system plays a crucial role in mediating the reinforcing effects of nicotine. Recently, acute high frequency repetitive transcranial magnetic stimulation (rTMS) of frontal brain regions has been shown to efficiently modulate the mesolimbic dopamine systems in both animals and humans. For this reason, we investigated whether 10 high-frequency (10Hz) rTMS treatments over the left dorsolateral prefrontal cortex can help people to withdraw smoking in comparison to placebo rTMS.
Smokers seeking to quit are recruited through newspaper advertisements. Participants were randomized to 10 days of either real or placebo high frequency rTMS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Smoking over 20 Cig a day -
epilepsy, psychiatry history
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Real high frequency rTMS Transcranial Magnetic Stimulation 10Hz The patients will undergo a series of treatments of high frequency rTMS Sham high frequency rTMS Magnetic stimulation using a special sham coil The patients will receive a series of sham treatments.
- Primary Outcome Measures
Name Time Method number of cigarettes smoked
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sheba Medical Center
🇮🇱Ramat Gan, Israel