Interchromosomal Insertion Carriers PGT-SR

Completed

• Conditions: Infertility; Interchromosomal Breakpoint

• Registration Number: NCT04978402
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Interchromosomal insertions (IT) are rare and complex structural rearrangements. Theoretically, the risk to have a child to term with a malformation or mental retardation can reach 50% related to the proportion of unbalanced gametes produced from behavior of chromosomes during meiosis. However, the meiotic segregation of IT has rarely been studied. This study provide an accurate reproductive risk of IT carriers resulting from a combined analysis of Sperm-FISH and preimplantation genetic testing for structural rearrangement (PGT-SR) management of IT carriers.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10-01
• Primary Completion: 2019-04-01
• Study Completion: 2019-04-01
• Status Verified: 2021-07
• Study First Submitted: 2021-07-19
• Study First Submitted QC: 2021-07-19
• Last Update Submitted: 2021-07-19
• Study First Posted: 2021-07-27
• Last Update Posted: 2021-07-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

Not provided

Exclusion Criteria

• Patient who reject the study protocol

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
estimate the IT carrier's reproductive risk	day 1	estimate the IT carrier's reproductive risk by investigation of the meiotic segregation of sperm from IT carriers by FISH and evaluate PGT-SR results of male and female IT carriers

Trial Locations

Locations (1)

Uhmontpellier; 🇫🇷 Montpellier, France