Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics
- Registration Number
- NCT00888186
- Lead Sponsor
- Uppsala University
- Brief Summary
The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose. The hypothesis is that different dyskinesias (dystonia, chorea) correlate to different levels of levodopa concentrations, as detected in plasma.
- Detailed Description
By using duodenal infusion of levodopa/carbidopa, the plasma concentration of levodopa can be kept fairly constant. Different doses, 10-20% higher or lower than the individually optimized dose will be used. Motor performance is captured by video recordings to be compared to/correlated with plasma levodopa concentrations.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5
Inclusion Criteria
- Clinical diagnosis of idiopathic Parkinson's disease
- Ongoing treatment with Duodopa
- Occurrence of dyskinesias, difficult to manage
- Age 30-90 years
- Hoehn & Yahr stage 3-5 at worst
Exclusion Criteria
- Treatment with dopamine agonist or glutamate antagonist
- Dementia
- Psychosis
- Treatment with typical neuroleptics
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 2. Duodopa 20% too high dose levodopa/carbidopa - 4. Duodopa 20% too low dose levodopa/carbidopa - 5. Duodopa 10% too high dose levodopa/carbidopa - 1. Duodopa optimal dose levodopa/carbidopa - 3. Duodopa 10% too low dose levodopa/carbidopa -
- Primary Outcome Measures
Name Time Method Correlation between plasma levodopa concentration and choreatic dyskinesia, dystonia, and parkinsonism 3 days
- Secondary Outcome Measures
Name Time Method Correlation between choreatic dyskinesia, dystonia, and parkinsonism. 3 days
Trial Locations
- Locations (1)
Uppsala University Hospital
🇸🇪Uppsala, Sweden