Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics
Overview
- Phase
- Phase 4
- Intervention
- levodopa/carbidopa
- Conditions
- Parkinson Disease
- Sponsor
- Uppsala University
- Enrollment
- 5
- Locations
- 1
- Primary Endpoint
- Correlation between plasma levodopa concentration and choreatic dyskinesia, dystonia, and parkinsonism
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose. The hypothesis is that different dyskinesias (dystonia, chorea) correlate to different levels of levodopa concentrations, as detected in plasma.
Detailed Description
By using duodenal infusion of levodopa/carbidopa, the plasma concentration of levodopa can be kept fairly constant. Different doses, 10-20% higher or lower than the individually optimized dose will be used. Motor performance is captured by video recordings to be compared to/correlated with plasma levodopa concentrations.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of idiopathic Parkinson's disease
- •Ongoing treatment with Duodopa
- •Occurrence of dyskinesias, difficult to manage
- •Age 30-90 years
- •Hoehn \& Yahr stage 3-5 at worst
Exclusion Criteria
- •Treatment with dopamine agonist or glutamate antagonist
- •Psychosis
- •Treatment with typical neuroleptics
Arms & Interventions
1. Duodopa optimal dose
Intervention: levodopa/carbidopa
2. Duodopa 20% too high dose
Intervention: levodopa/carbidopa
3. Duodopa 10% too low dose
Intervention: levodopa/carbidopa
4. Duodopa 20% too low dose
Intervention: levodopa/carbidopa
5. Duodopa 10% too high dose
Intervention: levodopa/carbidopa
Outcomes
Primary Outcomes
Correlation between plasma levodopa concentration and choreatic dyskinesia, dystonia, and parkinsonism
Time Frame: 3 days
Secondary Outcomes
- Correlation between choreatic dyskinesia, dystonia, and parkinsonism.(3 days)