Research on the Clinical Effect of Effective Prescription in Treating Unstable Angina.
Phase 4
- Conditions
- Unstable Angina
- Interventions
- Drug: Anti-Platelet DrugsDrug: Lipid Regulating DrugsDrug: Coronary VasodilatorDrug: Gualou Xiebai Banxia Decoction & Danshen Decoction
- Registration Number
- NCT03171597
- Lead Sponsor
- Jun Li
- Brief Summary
This study evaluates the clinical efficacy of the famous prescription in the treatment of unstable angina pectoris. All of the patients will be divided into 4 arms according to their syndrome type. One of the arms will be treated by conventional western medicine, the other three will be treated by different Chinese herbal medicine prescription at the base of conventional western medicine.
- Detailed Description
Xuefu Zhuyu Decoction has the function of activating qi and promoting blood circulation, which will be used to treat patients with qi stagnation and blood stasis syndrome.
GualouXiebaiBanxia Decoction compounded with Danshen Decoction has the effect of promoting blood circulation and resolving phlegm, so it will be used for patients taht belong to phlegm and blood stasis type.
Shuanghe Decoction has the function of supplementing Qi and activating blood circulation, which will be used to treat patients with Qi deficiency and blood stasis syndrome.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 240
Inclusion Criteria
- Participants diagnosed with coronary heart disease through coronary angiography or coronary CTA;
Patients have at least one of these symptoms:
- The stability of the nature of angina pectoris changes, that is, frequent attacks of angina pectoris, serious degree and prolonged duration;
- Angina pectoris during rest;
- The recent occurrence of angina pectoris caused by mild physical activity in the last month.
Exclusion Criteria
- Patients dignosed with stable angina; Patients with acute myocardial infarction; Chest pain caused by congenital heart disease, valvular heart disease, severe neurosis or arrhythmia; The heart function grade is III or IV; Patients with acute cerebral infarction; Patients complicated with other serious primary diseases; Patients with acute infection in recent 2 weeks; Uncontrolled hypertension (the resting blood pressure >160/95mmHg within one week); Diabetics emerged with serious diabetic complications; Patients can't finish the questionnaire due to abnormal mental and nervous or mental disorders; Pregnant or lactating women.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description conventional western medicine Anti-Platelet Drugs Patients in this group will be treated by conventional western medicine, including anti-platelet drugss，lipid regulating drugs, coronary vasodilator, etc. Qi deficiency and blood stasis Lipid Regulating Drugs Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine. Qi stagnation and blood stasis Coronary Vasodilator Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine. Qi deficiency and blood stasis Anti-Platelet Drugs Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine. Qi deficiency and blood stasis Shuanghe Decoction Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine. Qi stagnation and blood stasis Lipid Regulating Drugs Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine. conventional western medicine Lipid Regulating Drugs Patients in this group will be treated by conventional western medicine, including anti-platelet drugss，lipid regulating drugs, coronary vasodilator, etc. Qi deficiency and blood stasis Coronary Vasodilator Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine. Phlegm and blood stasis Coronary Vasodilator Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine. Phlegm and blood stasis Gualou Xiebai Banxia Decoction & Danshen Decoction Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine. conventional western medicine Coronary Vasodilator Patients in this group will be treated by conventional western medicine, including anti-platelet drugss，lipid regulating drugs, coronary vasodilator, etc. Qi stagnation and blood stasis Anti-Platelet Drugs Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine. Phlegm and blood stasis Lipid Regulating Drugs Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine. Phlegm and blood stasis Anti-Platelet Drugs Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine. Qi stagnation and blood stasis Xuefu Zhuyu Decoction Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine.
- Primary Outcome Measures
Name Time Method Mortality Six months after drug intervention Death caused by cardiovascular disease
- Secondary Outcome Measures
Name Time Method Treadmill exercise test At baseline and 4 weeks after drug intervention The result will be positive or negative
Blood lipid At baseline and 4 weeks after drug intervention The unit is mmol/L.
The incidence of myocardial infarction or heart failure Six months after drug intervention Myocardial enzymes At baseline and 4 weeks after drug intervention The unit is mmol/L