Research on the Clinical Effect of Effective Prescription in Treating Unstable Angina.
Overview
- Phase
- Phase 4
- Intervention
- Anti-Platelet Drugs
- Conditions
- Unstable Angina
- Sponsor
- Jun Li
- Enrollment
- 240
- Primary Endpoint
- Mortality
- Last Updated
- 8 years ago
Overview
Brief Summary
This study evaluates the clinical efficacy of the famous prescription in the treatment of unstable angina pectoris. All of the patients will be divided into 4 arms according to their syndrome type. One of the arms will be treated by conventional western medicine, the other three will be treated by different Chinese herbal medicine prescription at the base of conventional western medicine.
Detailed Description
Xuefu Zhuyu Decoction has the function of activating qi and promoting blood circulation, which will be used to treat patients with qi stagnation and blood stasis syndrome. GualouXiebaiBanxia Decoction compounded with Danshen Decoction has the effect of promoting blood circulation and resolving phlegm, so it will be used for patients taht belong to phlegm and blood stasis type. Shuanghe Decoction has the function of supplementing Qi and activating blood circulation, which will be used to treat patients with Qi deficiency and blood stasis syndrome.
Investigators
Jun Li
Chief Physician
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Eligibility Criteria
Inclusion Criteria
- •Participants diagnosed with coronary heart disease through coronary angiography or coronary CTA;
- •Patients have at least one of these symptoms:
- •The stability of the nature of angina pectoris changes, that is, frequent attacks of angina pectoris, serious degree and prolonged duration;
- •Angina pectoris during rest;
- •The recent occurrence of angina pectoris caused by mild physical activity in the last month.
Exclusion Criteria
- •Patients dignosed with stable angina; Patients with acute myocardial infarction; Chest pain caused by congenital heart disease, valvular heart disease, severe neurosis or arrhythmia; The heart function grade is III or IV; Patients with acute cerebral infarction; Patients complicated with other serious primary diseases; Patients with acute infection in recent 2 weeks; Uncontrolled hypertension (the resting blood pressure \>160/95mmHg within one week); Diabetics emerged with serious diabetic complications; Patients can't finish the questionnaire due to abnormal mental and nervous or mental disorders; Pregnant or lactating women.
Arms & Interventions
Qi stagnation and blood stasis
Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine.
Intervention: Anti-Platelet Drugs
Qi deficiency and blood stasis
Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine.
Intervention: Shuanghe Decoction
conventional western medicine
Patients in this group will be treated by conventional western medicine, including anti-platelet drugss，lipid regulating drugs, coronary vasodilator, etc.
Intervention: Anti-Platelet Drugs
conventional western medicine
Patients in this group will be treated by conventional western medicine, including anti-platelet drugss，lipid regulating drugs, coronary vasodilator, etc.
Intervention: Lipid Regulating Drugs
conventional western medicine
Patients in this group will be treated by conventional western medicine, including anti-platelet drugss，lipid regulating drugs, coronary vasodilator, etc.
Intervention: Coronary Vasodilator
Qi deficiency and blood stasis
Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine.
Intervention: Anti-Platelet Drugs
Qi deficiency and blood stasis
Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine.
Intervention: Lipid Regulating Drugs
Qi deficiency and blood stasis
Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine.
Intervention: Coronary Vasodilator
Qi stagnation and blood stasis
Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine.
Intervention: Lipid Regulating Drugs
Qi stagnation and blood stasis
Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine.
Intervention: Coronary Vasodilator
Qi stagnation and blood stasis
Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine.
Intervention: Xuefu Zhuyu Decoction
Phlegm and blood stasis
Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine.
Intervention: Anti-Platelet Drugs
Phlegm and blood stasis
Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine.
Intervention: Lipid Regulating Drugs
Phlegm and blood stasis
Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine.
Intervention: Coronary Vasodilator
Phlegm and blood stasis
Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine.
Intervention: Gualou Xiebai Banxia Decoction & Danshen Decoction
Outcomes
Primary Outcomes
Mortality
Time Frame: Six months after drug intervention
Death caused by cardiovascular disease
Secondary Outcomes
- Blood lipid(At baseline and 4 weeks after drug intervention)
- Treadmill exercise test(At baseline and 4 weeks after drug intervention)
- The incidence of myocardial infarction or heart failure(Six months after drug intervention)
- Myocardial enzymes(At baseline and 4 weeks after drug intervention)