Kappa Opioid Receptor Imaging in Anorexia

Terminated

• Conditions: Anorexia Nervosa
• Interventions: Other: Positron emission tomography (PET) imaging

• Registration Number: NCT02240797
• Lead Sponsor: NYU Langone Health

Brief Summary

The purpose of this study is to use positron emission tomography (PET) imaging and magnetic resonance imaging (MRI) to understand the brain function of individuals with anorexia nervosa and healthy controls.

Detailed Description

This is a 3-year study involving n=7 women with anorexia nervosa - recovered (AN-REC) from restricting subtype that have achieved a body mass index (BMI) \> 18.5 in the past year, are medication free, range in age from 18-55 years and n=7 healthy (medical and psychiatric statues) age- and weight-matched controls who are invited to participate in a medical and psychiatric evaluation, neuroendocrine assessments, one magnetic resonance imaging (MRI) study and one positron emission tomography (PET) study kappa opioid receptor (KOR) 11-carbon (11C) \[11C\]PKAB and PET. Subjects will be asked to provide written informed consent after full explanation of all study procedures and risks and benefits related to study participation. On the screening day a full medical evaluation including blood work, urine analyses, toxicology, electrocardiogram (ECG) and physical exam will be performed.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-09
• Study First Submitted: 2014-09-09
• Study First Submitted QC: 2014-09-12
• Study First Posted: 2014-09-16
• Primary Completion: 2016-03
• Study Completion: 2016-03
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-15
• Last Update Posted: 2016-08-17

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 7

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Anorexia Nervosa - Recovered (AN-REC)	Positron emission tomography (PET) imaging	Anorexia Nervosa - Recovered (AN-REC)
Healthy Control (HC)	Positron emission tomography (PET) imaging	Healthy Control (HC)

Primary Outcome Measures

Name	Time	Method
Volume of distribution (VT) (i.e., KOR binding) using [11C]PKAB and PET imaging	Two months	In this study we are using the KOR radioligand \[11C\]PKAB and PET to investigate group differences in cerebral KOR binding potential in 7 AN-REC and 7 healthy controls (HCs).

Trial Locations

Locations (1)

NYU School of Medicine; 🇺🇸 New York, New York, United States