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Clinical Trials/NCT05564442
NCT05564442
Recruiting
N/A

Comparative Evaluation of Different Pain Alleviating Methods During Intra-oral Local Anesthetic Injections in Children : A Randomized Controlled Trial

Minia University1 site in 1 country224 target enrollmentJune 5, 2022

Overview

Phase
N/A
Intervention
20% benzocaine gel
Conditions
Anesthesia, Local
Sponsor
Minia University
Enrollment
224
Locations
1
Primary Endpoint
Baseline Heart Rate ( beats/min )
Status
Recruiting
Last Updated
3 years ago

Overview

Brief Summary

The aim of study is to compare the efficacy of various pain alleviating methods by application of Emla gel, TENS, and topical cooling of injection sites compared with 20% benzocaine gel in reducing pain in children requiring anesthesia during routine dental procedures.

Detailed Description

The main concern of the pediatric dentist is to achieve the cooperation of the child in the dental clinic during various pediatric procedures. Administering anesthesia to pediatric patients is the most challenging part of the process. The real fear of the child during a pediatric procedure is painful local anesthetic (LA) injections. The mere sight of needle and syringes cause psychological trauma to the child and thus interferes with the behavior management of a child. Reducing the fear of pain during LA injections gains the confidence of the child toward the dentist, thus achieving the cooperation of the child during treatment . To reduce the pain during administration of the LA injection, several pharmacological and non-pharmacological methods such as use of topical anesthetics, slowing down the rate of infiltration, distracting the children, vibrating the tissue of the injection site during injection, heat and ice application before the injection have been tested. Application of flavored topical anesthetic gel is most commonly practiced in pediatric dentistry . Various techniques are available to decrease discomfort during LA injections. Transcutaneous electrical nerve stimulation (TENS) works on the principle of gate control theory. Transcutaneous electrical nerve stimulation directly stimulates the nerves by electrical impulses of short duration and small amplitude for pain reduction during LA injections . Transcutaneous electrical nerve stimulation proved to be more comfortable and beneficial in reducing pain and anxiety during LA injections. Studies have reported that it lowers edema, nerve conduction velocities, cellular metabolism, and local blood flow . Topical anesthetic agents are commonly used before the administration of LA . 2% lignocaine gel produces surface anesthesia; however, it has a limited capacity of penetrating deep into tissues. A cutaneous topical anesthetic which was first used in dermatology in the 1980s, Another recommended method to eliminate the pain of injection is cooling of the injection site. This technique has been used in sprains, burns, fractures, bruises, insect bites, and sports injuries eutectic mixture of lignocaine and prilocaine (EMLA) - "a 1:1 mixture of 2.5% prilocaine and 2.5% lidocaine". The first trial to administer EMLA cream in the mucosal surface was first described by Holst and Evers.

Registry
clinicaltrials.gov
Start Date
June 5, 2022
End Date
February 1, 2023
Last Updated
3 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Minia University
Responsible Party
Principal Investigator
Principal Investigator

Bahy ibrahim abdelfatah ellmelegy

Principal investigator

Minia University

Eligibility Criteria

Inclusion Criteria

  • Class I and Class II relaying on ASA classification
  • Children of the age-group 6-10 years were included in this study.
  • Children who are never exposed to TENS, EMLA jelly,
  • Children who require LA injections and in whom parental consent was obtained.
  • Patients requiring LA for dental procedures such as pulpotomy, or extraction procedure.
  • Definitely positive on frankel scale.

Exclusion Criteria

  • Children with epileptic disorder.
  • Children with a history of cardiac and bleeding disorder.
  • Immature children who cannot understand the concept of pain.
  • Physically and mentally challenged children.
  • Subjects allergic to LA drugs or cartridge components
  • Patients having behavioral management problems.
  • Patients having previous negative dental experience.

Arms & Interventions

Group I: Children received 20% benzocaine gel

Comparative Evaluation of Different Pain Alleviating Methods During Intra-oral Local Anesthetic Injections

Intervention: 20% benzocaine gel

Group II: Children received TENS stimuli

Comparative Evaluation of Different Pain Alleviating Methods During Intra-oral Local Anesthetic Injections

Intervention: Transcutaneous electric nerve stimuli

Group III: Children received EMLA gel.

Comparative Evaluation of Different Pain Alleviating Methods During Intra-oral Local Anesthetic Injections

Intervention: Emla gel

Group IV: Children received ice application at injection site

Comparative Evaluation of Different Pain Alleviating Methods During Intra-oral Local Anesthetic Injections

Intervention: Ice application

Outcomes

Primary Outcomes

Baseline Heart Rate ( beats/min )

Time Frame: mean measurement when the child is seated on the dental chair until right before the injection at 2 minute intervals. time frame was approximately Minute 0 - 2 ]

Heart Rate will be measured by using digital manometerReading will be recorded at 2-minute intervals and the mean heart rate measurement will be calculated.

Heart Rate Measurement after Local Anaesthetic Administration( beats/min )

Time Frame: After local anaesthetic solution delivery. Time frame is approximately minute 2 - 4

Heart Rate will be measured by using digital manometer .Readings will be recorded at 2-minute intervals and the mean heart rate measurement will be calculated.

Baseline blood pressure systolic and diastolic ( mm Hg)

Time Frame: mean measurement when the child is seated on the dental chair until right before the injection at 2 minute intervals. time frame was approximately Minute 0 - 2 ]

The blood pressure is most often measured in the arm when the patient is seated. Blood pressure readings taken in supine position tend to be lower than those taken in sitting position. Standards for blood pressure readings are based upon the seated position using the right arm.

Blood pressure measurment (systolic and diastolic)after local anesthetic administration ( mm Hg )

Time Frame: After local anaesthetic solution delivery. Time frame is approximately minute 2 - 4

The blood pressure is most often measured in the arm when the patient is seated. Blood pressure readings taken in supine position tend to be lower than those taken in sitting position. Standards for blood pressure readings are based upon the seated position using the right arm.

The FLACC scale or Face, Legs, Activity, Cry, Consolability scale

Time Frame: Approximately 2-4 minute after injection.

The scale is scored in a range of 0-10 with 0 representing no pain. The scale has five criteria, which are each assigned a score of 0, 1 or 2.

Wong-Baker Faces Pain Rating Scale

Time Frame: Approximately 2-4 minute after injection.

The scale shows a series of faces ranging from a happy face at 0, or "no hurt", to a crying face at 10, which represents "hurts like the worst pain imaginable".

Study Sites (1)

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