Ultrasonography Guided Brain Lesions Resection:

• Conditions: Patients Who Are Diagnosed to Have Intracranial Lesions

• Registration Number: NCT04569526
• Lead Sponsor: Assiut University

Brief Summary

1. Evaluate the clinical value of intraoperative ultrasonography as a real-time guidance

2. Combination of data of MRI Tractography and intra operative ultrasonography will be useful in good localization of lesions or not .

3. Maximal safe resection .

Detailed Description

Accurate pre and intraoperative localization of Brain lesions is a challenge in neurosurgery specially deep intra cerebral lesions. Stereotaxy and neuronavigator played a major role in preoperative and intraoperative evaluation of exact location of intra cerebral lesions, the main drawbacks of using steriotaxy and neuronavigator that they are time consuming, complicated and expensive.(1) Nowadays we use MRI Tractography as preoperative imaging to localize lesions and there relation to neural tracts specially in eloquent brain areas, and also intraoperative ultrasonography Which act as a real-time, unexpansive and relatively simple tool for intraoperative visualization of the lesion's location, size, extent and its relationship with the surrounding tissue, also it can reveal the lesion's blood supply, it can measure the rate and direction of arterial blood flow.(2,3,4) Intraoperative ultrasonic imaging was first applied as a real-time navigation system in neurosurgery in 1980. (5) In this research we will combine the use of preoperative MRI tractography with intra operative ultrasonography in accurate localization of brain lesions and its relation with important tracts and if this combination will be beneficial and add to the safety of excision of lesions or not.

Study Timeline

• Status Verified: 2020-09
• Study First Submitted: 2020-09-24
• Study First Submitted QC: 2020-09-24
• Last Update Submitted: 2020-09-24
• Study Start: 2020-09-25
• Study First Posted: 2020-09-30
• Last Update Posted: 2020-09-30
• Primary Completion: 2021-07-25
• Study Completion: 2021-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Patients who are diagnosed to have Intracranial lesions Patients with recurrent lesions

Exclusion Criteria

• Patients who are unfit for surgery Patients who have multifocal lesions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Extent of resection of the lesion	48 hours	Extent of resection of the lesion evaluated by comparing pre operative and post operative MRI

Secondary Outcome Measures

Name	Time	Method
post operative complication	one month	post operative complication evaluated by full neurological examination