Expression Levels of Nicotinamide Metabolism-related Protein (NMAP) in Newly Diagnosed Renal Cancer and Non-renal Cancer Populations
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- NMAP level study
研究概览
简要总结
This study aims to observe the difference between NMAP (nicotinamide metabolism associated protein) serum levels in primary diagnosed renal cancer patients and non-renal cancer patient controls, plot the ROC curve and establish appropriate cut-off values.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The tumor group patients were found to have renal or hepatic mass, plan to receive surgical treatment (except for radiofrequency ablation, cryoablation, etc., which were not available for pathological examination). The control group patients were ruled out of tumor based on radiological tests and commonly used tumor biomarkers
- •Age ≥ 18 years old and able to provide written informed consent;
- •Have not received any systemic or topical treatment for kidney/liver tumors.
- •Cardiopulmonary, liver and kidney functions are able to tolerate surgery and can comply with research requirements.
排除标准
- •The investigators believe that the subject may be unsuitable for inclusion due to severe concurrent diseases, infections, and etc.
- •The subjects is known or suspected of other malignancies.
- •There has been another history of malignancy in the past 5 years.
- •Major surgery (surgery requiring general anesthesia) was performed within 4 weeks prior to screening visits.
研究组 & 干预措施
Renal cancer group
Patients which imaging studies have found renal mass, plan to receive surgery (except for radiofrequency ablation, cryoablation, etc.), about 100.
干预措施: Blood test (Other)
Urothiasis group
Patients which imaging studies have found renal or ureteral stones, and rule out of renal mass, about 100.
干预措施: Blood test (Other)
Renal cysts group
Patients which imaging studies have found renal cysts (simple or complex) about 100.
干预措施: Blood test (Other)
Liver cancer group
Patients which imaging studies have found hepatic mass, plan to receive surgery (except for radiofrequency ablation, cryoablation, etc.), about 100.
干预措施: Blood test (Other)
结局指标
主要结局
NMAP level study
时间窗: September 2019-September 2021
To observe the difference in the expression level of nicotinamide metabolism related protein (NMAP) in the serum of newly diagnosed renal cancer and non-renal cancer patients. Draw the NMAP ROC curve and establish the appropriate Cut-off value to analyze its sensitivity and specificity.
次要结局
- NMAP plus other tumor biomarkers study(September 2019-September 2021)
研究者
Jie Ding
Attending doctor
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine