NCT07417774Enrolling By Invitation不适用
Liquid Biopsy in Glioblastoma Treated With Chemoradiation and an Oxygen Therapeutic
NuvOx LLC4 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年12月8日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 40
- 试验地点
- 4
- 主要终点
- Tumor hypoxia biomarkers
研究概览
简要总结
The goal of this sub-study of the RESTORE trial is to identify biomarkers associated with tumor hypoxia, identify biomarkers that differentiate pseudoprogression from true progression, and correlate biomarkers with clinical outcomes.
详细描述
Blood samples for liquid biopsy will be collected at the same time as the scheduled blood draws in the RESTORE study and analyzed by FYR Diagnostics.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects must be enrolled in the RESTORE study (NCT03862430) and provide written informed consent for the RESTORE LB sub-study
排除标准
- 未提供
结局指标
主要结局
Tumor hypoxia biomarkers
时间窗: until disease progression and up to 5 years
Identify differentially expressed tumor hypoxia markers in newly-diagnosed glioblastoma subjects treated with NanO2 versus placebo in the RESTORE study.
次要结局
- Biomarker expression(until disease progression and up to 5 years)
- Relationship between biomarker levels, MGMT methylation status, and survival outcomes(until disease progression and up to 5 years)
研究者
研究点 (4)
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