eural correlates of chronic fatigue syndrome - Neural correlates of chronic fatigue syndrome

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 160 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•All subjects:
•>= 18 years <= 65 years;
•Able to speak read and write Dutch;
•Predominantly right handedness;
•Give written informed consent;;Patients:
•Meet the 1994 US centre for Disease Control and Prevention criteria for Chronic Fatigue Syndrome (revised 2003)
•Severely fatigued, i.e. scoring >= 40 on the subscale fatigue severity of the Checklist Individual Strength (CIS);
•Severely disabled; i.e scoring >= 700 in the Sickness Impact Profile r_08 (SIPr08) total score; ;Healthy control:
•Scoring <= 35 on the subscale fatigue severity of the Checklist Individual Strength (CIS);
•Scoring < 700 in the Sickness Impact Profile r_08 (SIPr08) total score;

•Infection or inflammation at the day of testing (Body temperature >= 38°C);
•Any injury to the right hand that confounds hand grip performance;
•A maximal voluntary contraction (MVC) that exceeds the maximal dispersion of the hand grip device (>400 Newton)
•(History of) long term use of anti-depressants, anti-anxiety medications, beta-blockers benzodiazepines, psycho-stimulants or sleep medication;
•Current major depressive or bipolar disorder
•(History of) Schizophrenia or delusional disorder.
•(History of) Anorexia nervosa or bulimia nervosa
•(History of) alcohol or substance abuse
•Severe obesity (BMI >= 40)
•Abnormal hearing or (uncorrected) vision;;MRI Contraindications:
•Irremovable metal objects in or around the body (e.g. braces, pacemaker, metal fragments, hearing devices);
•Claustrophobia;
•(History of) Epilepsy;
•Possible pregnancy or breastfeeding;

发起方

niversitair Medisch Centrum Sint Radboud