Examining unique pharmacology intervention for heavy drinking alcohol dependent individuals who smoke

ABMRF/The Foundation for Alcohol Research (USA)0 个研究点目标入组 30 人开始时间: 2013年10月29日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Between 18 and 75 years old
•2. DSM-IV diagnoses of both alcohol and nicotine co-dependency, with heavy use of alcohol (men = 5 Standard Drink Units [SDUs], and women = 4 SDUs a day) and cigarettes (=10 cigarettes per day) on average during the last 90 days before screening
•3. Interested in receiving treatment for both drinking and smoking (either reducing or stopping both substances; or reducing one substance and stopping the other).

•1. Current (i.e. past year) DSM-IV diagnosis of dependence on any psychoactive substance other than alcohol and nicotine
•2. Lifetime DSM-IV diagnosis of schizophrenia, bipolar disorder, or other psychosis
•3. Past year diagnosis of major depression, anxiety disorders, eating disorders
•4. Risk of suicide (e.g. active plan, or recent attempt in last year)
•5. Positive urine drug screen at baseline for any illegal substance other than marijuana
•6. Important alcohol withdrawal symptoms, as assessed by a Clinical Institute Withdrawal Assessment for Alcohol revised (CIWA-Ar) score >10
•7. History of hospitalization for alcohol intoxication delirium, alcohol withdrawal delirium or seizure
•8. Participation in any research study for alcoholism and/or smoking treatment within 3 months prior to signing the consent document
•9. Pharmacological treatment with naltrexone, acamprosate, topiramate, disulfiram, nicotine replacement, bupropion, varenicline within 1 month prior to randomization
•10. Current use of psychotropic medications or medications that interfere with the metabolism of BACL, history of allergy to BACL or medical contraindications to take BACL
•11. Severe medical diseases, such as cancer, cirrhosis, chronic kidney failure, chronic neurological disorders
•12. Females who were of child bearing potential and not practicing effective birth control.

发起方

ABMRF/The Foundation for Alcohol Research (USA)