Effects of the Geriatric Nutritional Risk Index (GNRI), Mini Nutritional Assessment-Short Form (mNA-SF), and Systemic Immune-Inflammation Index (SII) on Postoperative Morbidity and Mortality in Geriatric Patients Undergoing Gastrointestinal Surgery
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Systemic Immune-Inflammation Index (SII)
研究概览
简要总结
The purpose of this study was to compare the sensitivity and specificity of the Geriatric Nutritional Risk Index (GNRI), Mini Nutritional Assessment Scale-Short Form (mNA-SF) and Systemic Immune-Inflammatory Index (SII) values calculated in the preoperative evaluation in patients over 65 years of age who underwent gastrointestinal surgery, in predicting morbidity and mortality in the postoperative period.
详细描述
It is crucial to evaluate the impact of nutritional status and systemic inflammation markers on postoperative outcomes in geriatric patients undergoing gastrointestinal surgery.
Nutritional status has a decisive impact on the development of morbidity and mortality in geriatric patients. The risk of malnutrition is particularly high in the geriatric patient population undergoing gastrointestinal surgery. Predicting postoperative outcomes in these patient groups is becoming increasingly important. To this end, many different risk scoring systems have been developed.
Low nutritional scores and increased inflammatory responses are associated with high mortality, prolonged hospitalization and intensive care unit stays, and complications. The primary goal of preoperative risk scoring is to predict potential complications before, during, and after surgery, and to minimize risks and mortality by attempting to prevent them.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled to undergo gastrointestinal surgery.
- •Age 65 years and older.
- •ASA (American Society of Anesthesiologists) physical status class 3 or
- •Mini-Mental State Examination (MMSE) score of 21 or higher
排除标准
- •Patients who do not consent to participate in the study.
- •Patients with acute infection during the preoperative period.
- •Patients who received albumin replacement in the preoperative period.
- •Patients with a Mini-Mental State Examination (MMSE) score below 21.
研究组 & 干预措施
Geriatric Gastrointestinal Surgery Patients.
This group consists of 200 geriatric patients aged 65 and older who are scheduled to undergo gastrointestinal surgery. Participants are within the ASA 3-4 risk groups and must have a Mini-Mental State Examination (MMSE) score of 21 or higher to be included.
干预措施: Delirium Assessment Protocol (Other)
Geriatric Gastrointestinal Surgery Patients.
This group consists of 200 geriatric patients aged 65 and older who are scheduled to undergo gastrointestinal surgery. Participants are within the ASA 3-4 risk groups and must have a Mini-Mental State Examination (MMSE) score of 21 or higher to be included.
干预措施: Preoperative Risk Scoring (Other)
Geriatric Gastrointestinal Surgery Patients.
This group consists of 200 geriatric patients aged 65 and older who are scheduled to undergo gastrointestinal surgery. Participants are within the ASA 3-4 risk groups and must have a Mini-Mental State Examination (MMSE) score of 21 or higher to be included.
干预措施: Postoperative Morbidite and Mortality Monitoring (Other)
结局指标
主要结局
Systemic Immune-Inflammation Index (SII)
时间窗: Preoperative (Baseline)
Calculated as (Platelets x Neutrophils) / Lymphocytes from preoperative blood samples.The unit of measure is cells per microliter.
Geriatric Nutritional Risk Index (GNRI) as a predictor of postoperative complications
时间窗: Preoperative (Baseline)
GNRI will be calculated using serum albumin and body weight. Scores will be used to categorize patients' nutritional risk.Units on a scale of 0 to 120, where lower scores indicate higher nutritional risk.
Mini Nutritional Assessment-Short Form (mNA-SF) score
时间窗: Preoperative (Baseline)
A 6-question survey to screen for malnutrition.Measured on a scale of 0 to 14 points, where 0-7 indicates malnourishment.
次要结局
- Postoperative Morbidity(Up to 30 days post-surgery)
- Incidence of Delirium(Preoperative to discharge)
- Length of Hospital and ICU Stay(Total duration of hospitalization)
- Postoperative Mortality Rate(30, 60, and 90 days post-surgery)
研究者
Minel Neslihan
Assistant Doctor
Dr. Lutfi Kirdar Kartal Training and Research Hospital