Effects of Epinephrine and I.V. Needle on CPR Outcome
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 904
- 试验地点
- 1
- 主要终点
- survival to hospital discharge with neurologic outcome
研究概览
简要总结
Intravenous epinephrine has been part of the guidelines for cardiopulmonary resuscitation since the start. It improves outcome in animal studies, but has never been investigated in a controlled study in humans. Epidemiologic data indicate that it is an independent negative predictor for survival. If this is true in a controlled randomized study, it could be due to effects of the drug itself or more likely due to reduced quality of chest compressions and ventilations due to the time spent on placing an I.V. needle and injecting drugs.
详细描述
In a randomized, controlled study of all out-of-hospital cardiac arrest patients in Oslo, Norway, half the patients are treated according to the international guidelines for advanced CPR, and the other half according to the same guidelines, except for no I.V. needle or drugs are given until 5 minutes after eventual return of spontaneous circulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cardiac arrest out-of-hospital
排除标准
- •<18 years old
- •Trauma as cause of arrest
研究组 & 干预措施
IV yes
Intravenous needle Epinephrine q 3 min during CPR Atropine 3 mg in initial asystole Amiodarone 300 mg iv after repeated failed defibrillation attempts
干预措施: Epinephrine (Drug)
IV yes
Intravenous needle Epinephrine q 3 min during CPR Atropine 3 mg in initial asystole Amiodarone 300 mg iv after repeated failed defibrillation attempts
干预措施: Intravenous needle (Device)
IV yes
Intravenous needle Epinephrine q 3 min during CPR Atropine 3 mg in initial asystole Amiodarone 300 mg iv after repeated failed defibrillation attempts
干预措施: Atropine (Drug)
IV yes
Intravenous needle Epinephrine q 3 min during CPR Atropine 3 mg in initial asystole Amiodarone 300 mg iv after repeated failed defibrillation attempts
干预措施: Amiodarone (Drug)
结局指标
主要结局
survival to hospital discharge with neurologic outcome
时间窗: discharge from hospital
次要结局
- admit to hospital with spontaneous circulation(hospital admission)
- one year survival with neurologic outcome(one year after hospital discharge)
研究者
Petter Andreas Steen
Professor Acute Medicine
University of Oslo