Qatar Universal Diabetes Outcomes (QUDOS) Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Enrollment
- 475
- Locations
- 1
- Primary Endpoint
- Diabetes Complications (Nephropathy, Neuropathy, Retinopathy)
Study Overview
Brief Summary
QUDOS is a cross-sectional population study aiming to answer key questions about diabetes and its complications in Qatar as well as identify factors associated with the development and progression of diabetes complications.
Detailed Description
QUDOS aims to gain a better understanding of diabetes in primary and secondary care over a period of 24 months.
A range of patients with diabetes will be sampled (including those with Type 1 diabetes as this group is under-studied in Qatar). This will be important in designing appropriate intervention plans that will improve diabetic patients' health conditions to prevent or delay the onset of complications and will provide a strong foundation for longitudinal study.
The broad objectives of the study are:
QUDOS 1: Aims to recruit 1,700 diabetic patients (including 200 with type 1 diabetes mellitus (independent of healthcare setting)) attending the hospitals and primary care and to collect the following data:
- Demographics: age, sex, ethnicity, socio-economic background, smoking status;
- Anthropometrics: vital signs, height, weight, body fat percentage, fat mass, neck and waist circumference;
- Medical History: medications, complications, comorbidities, latest HbA1c and lipid profiles and family medical history;
- Routine laboratory data;
- Lifestyle: diet, physical activity,;
- Sleep: quality and daytime sleepiness;
- Cognition and Mental Health: depression, anxiety, stress and memory;
- Diabetes microvascular complications: diabetic neuropathy, urine albumin/creatinine ratio; routine retinal screening data.
- Gut microbiome from a stool sample
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Type 1 and Type 2 diabetes mellitus;
- •Male or Female;
- •Resident in Qatar;
- •MENA birthplace and family origin;
- •18-70 years old;
- •Capable to give informed consent and complete the study.
Exclusion Criteria
- •Known pregnancy or planning pregnancy during the duration of study;
- •Congenital disorders;
- •Terminal illness;
- •Enrolled in a clinical trial involving medication;
- •Uncontrolled mental illness preventing participation;
- •Those who have already experienced a definitive microvascular complication:
- •i. End-stage renal disease; ii. Major amputation; iii. Blindness.
Outcomes
Primary Outcomes
Diabetes Complications (Nephropathy, Neuropathy, Retinopathy)
Time Frame: Baseline (Cross-Sectional)
Our primary analyses will be conducted to explore the potential cross-sectional relationships amongst proposed factors related to type 2 diabetes complications
Secondary Outcomes
- Sleep and sleep related breathing disorders(Baseline (Cross-Sectional))
- Mental Health(Baseline (Cross-Sectional))
- Physical activity(Baseline (Cross-Sectional))