ACTRN12617000469314
Suspended
未知
An examination of whether measures of brain function and structure in subacute post-stroke aphasia predict language recovery (naming and comprehension) and word retrieval treatment response at 3 months and 6 months post stroke-onset.
Professor David Copland0 sites115 target enrollmentMarch 31, 2017
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Professor David Copland
- Enrollment
- 115
- Status
- Suspended
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •People with aphasia:
- •\- Single, first, left hemisphere stroke (as confirmed by CT/MRI) and speech and language impairment as identified by a speech pathologist or other relevant medical, nursing or allied health staff
- •\-Below the aphasia cut\-off (93\.8 AQ) on the Western Aphasia Battery \- Revised (WAB\-R) or asphasia (including high level language deficits) as identified by a speech pathologist or other relevant medical, nursing or allied health staff
- •\- MRI compatibility, and able to complete behavioural battery between 2 and 6 weeks post\-stroke
- •\- Have sufficient vision and hearing to complete the imaging and behavioural tasks
- •\- Medically stable and able to attend and participate in a therapy program (8 weeks)
- •\- English as a primary language prior to stroke
- •Control Group:
- •\- healthy older adults matched for age and gender.
Exclusion Criteria
- •People with aphasia:
- •\- Any other neurological disease or disorder, mental illness, head trauma, alcoholism, cerebral tumour or abscess.
- •\- Any metals present in the body or other contraindications for MRI including claustrophobia.
- •\- Current diagnosis of major clinical depression or other mental health condition that may affect participation.
- •\- Severe dysarthria or apraxia of speech as determined by a speech pathologist.
- •\- Severe auditory comprehension deficits as determined by the WAB\-R which would preclude following directions for the scan.
- •\- Substance abuse or dependence in the last 12 months.
- •Healthy controls:
- •\- Any brain/neurological disorder, mental illness, head trauma, alcoholism and cerebral tumour
- •\- Any contraindications for MRI – claustrophobia or metals in the body e.g., pacemaker, heart valve, dental bridge metal mesh implants/clips/wire sutures, hearing implant etc.
Outcomes
Primary Outcomes
Not specified
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