Do measures of brain activity predict recovery of the ability to communicate after stroke and predict response to speech therapy?

Not Applicable

Suspended

• Conditions: Aphasia post stroke; Stroke - Ischaemic; Stroke - Haemorrhagic

• Registration Number: ACTRN12617000469314
• Lead Sponsor: Professor David Copland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-03-31
• Last Update Posted: 2 November 2020

Recruitment & Eligibility

• Status: Suspended
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

People with aphasia:
- Single, first, left hemisphere stroke (as confirmed by CT/MRI) and speech and language impairment as identified by a speech pathologist or other relevant medical, nursing or allied health staff
-Below the aphasia cut-off (93.8 AQ) on the Western Aphasia Battery - Revised (WAB-R) or asphasia (including high level language deficits) as identified by a speech pathologist or other relevant medical, nursing or allied health staff
- MRI compatibility, and able to complete behavioural battery between 2 and 6 weeks post-stroke
- Have sufficient vision and hearing to complete the imaging and behavioural tasks
- Medically stable and able to attend and participate in a therapy program (8 weeks)
- English as a primary language prior to stroke

Control Group:
- healthy older adults matched for age and gender.

Exclusion Criteria

People with aphasia:
- Any other neurological disease or disorder, mental illness, head trauma, alcoholism, cerebral tumour or abscess.
- Any metals present in the body or other contraindications for MRI including claustrophobia.
- Current diagnosis of major clinical depression or other mental health condition that may affect participation.
- Severe dysarthria or apraxia of speech as determined by a speech pathologist.
- Severe auditory comprehension deficits as determined by the WAB-R which would preclude following directions for the scan.
- Substance abuse or dependence in the last 12 months.

Healthy controls:
- Any brain/neurological disorder, mental illness, head trauma, alcoholism and cerebral tumour
- Any contraindications for MRI – claustrophobia or metals in the body e.g., pacemaker, heart valve, dental bridge metal mesh implants/clips/wire sutures, hearing implant etc.

Study & Design

• Study Type: Interventional
• Study Design: Not specified