Effect of Nasal Respiratory Support on the Sleep-wake cycle of Preterm Newborns

Not Applicable

• Conditions: The effect of a restrictive pulmonary disease and relevant medical interventions on Brain Hemodynamics.; Hyaline membrane disease; P22.0

• Registration Number: IRCT20120728010430N9
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 July 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Premature infants with the gestational age of 28 to 32 weeks still receiving nCPAP support 72 hours after birth whose first surfactant administration was during the first 2 hours after birth
Neonates receiving nCPAP support in order to maintain oxygen saturation (89%-95 at right hand) 72 hours after birth while CDP is at 4-6 cm H20 and FiO2 is at 30%-40%.

Exclusion Criteria

Perinatal Asphyxia (Apgar at fifth minute=0-3, Umbilical cord pH<7, Umbilical cord Bicarbonate < 12 mEq/L), Congenital Malformation
Neonates whose first surfactant administration is 2 hours after birth
Neonates with no surfactant administration
Neonates showing evidence of PDA through Echocardiography
Neonates under administration of Inotrope drugs
Neonates showing evidence of GM-IVH in grades III-IV in cranial sonography
Neonates with air leakage

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The number and duration of sleep-wake cycle. Timepoint: before intervention during a 6-hour period and during a 6-hour interval after intervention. Method of measurement: Using amplitude integrated EEG (Electroencephalography).