Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients
Not Applicable
Completed
- Conditions
- Oral Lichen Planus
- Interventions
- Device: CO2-Laser Treatment
- Registration Number
- NCT02154607
- Lead Sponsor
- Technical University of Munich
- Brief Summary
Oral Lichen Planus (OLP) is a common condition with its erosive variant occasionally presenting a management challenge to the clinician. In addition it can have debilitating consequences on the patients' quality of life. The malignant transformation of OLP has been well documented. The aims of this work were to measure the number of patients developing malignant transformationof OLP to squamous cell carcinoma (SCC) comparing patients undergoing traditional symptomatic treatments with those patients that were treated by CO2 laser from 2004 - 2011. Outcome measures were rated by incisional biopsy (histology Report).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 263
Inclusion Criteria
- Oral lichen planus
- Histological confirmation of diagnosis
- Patient willing for treatment
Exclusion Criteria
- Patient just does not want to participate as control/study group
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CO2-Laser Treatment CO2-Laser Treatment CO2-Laser Vaporisation was performed of OLP lesions under local anaesthesia.
- Primary Outcome Measures
Name Time Method stable disease of OLP (clinical observation) 1 year
- Secondary Outcome Measures
Name Time Method Development of oral cancer (histological report after incisional biopsy) 3 years