Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop

Not Applicable

Recruiting

• Conditions: Deep Brain Stimulation; Parkinson's Disease (PD)

• Registration Number: NCT07139093
• Lead Sponsor: Universitätsklinikum Hamburg-Eppendorf

Brief Summary

The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and tACS on the behavioural and neural level. To test if the interface works in patients with DBS, the investigators record EEG during synchronized tACS-DBS in several patients. The investigators hypothesize that they can apply tACS at the desired phase-lags relative to DBS pulses and confirm this with EEG measurements of the DBS and tACS artifact.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-08
• Study Start: 2025-08-01
• Study First Submitted: 2025-08-17
• Study First Submitted QC: 2025-08-22
• Last Update Submitted: 2025-08-22
• Study First Posted: 2025-08-24
• Last Update Posted: 2025-08-24
• Primary Completion: 2026-08
• Study Completion: 2026-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

• Provision of written informed consent by the patient
• Age 35 - 85
• patient groups: Parkinson's disease, essential tremor, dystonia
• >3 months after surgery for DBS

Exclusion Criteria

• Epilepsy or history of seizures
• Existence of heart pacemaker or other metal implants in the body (except DBS)
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Phase-locking success	during stimulation procedure	The investigators will measure the temporal precision of the locking of the tACS to the DBS pulses should be seen. To this end, the tACS-DBS artifact and the triggers given from the interface device will be analysed offline in MATLAB.

Trial Locations

Locations (1)

University Medical Center Hamburg-Eppendorf; 🇩🇪 Hamburg, Germany