Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis
- Conditions
- Periodontal Disease
- Registration Number
- NCT02010307
- Lead Sponsor
- Polak David
- Brief Summary
aggressive periodontitis is an inflammatory disease which damage the teeth supporting structures mostly in young patients. and has genetic basis.
a specific bacteria: Aggregatibacter actinomycetemcomitans (Aa) is associated with this disease, and found to damage leukocytes by using a specific leukotoxin.
in the research the investigators are aiming to find molecular and immunological basis to aggressive periodontitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 75
- patients in periodontal department
- healthy
- diagnosed with chronic/aggressive periodontal disease
- interested in participating the research
- diagnosed with diabetes, heart disease, immunosuppression, thrombocytopenia, clotting enzyme deficiency.
- using alcohol, or drugs
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method flow cytometry 12 hours after blood extraction the investigators use flow cytometry technique in order to determine the influence of gingival bacteria on the leukocytes, after culturing the two together.
- Secondary Outcome Measures
Name Time Method microscopy observation 12 hours after blood extraction the investigators use microscopy in order to determine the influence of gingival bacteria on the leukocytes, after culturing the two together
Trial Locations
- Locations (1)
Hadassah Medical Organization, Jerusalem, Israel
🇮🇱Jerusalem, Israel
Hadassah Medical Organization, Jerusalem, Israel🇮🇱Jerusalem, Israel