Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis

Polak David1 site in 1 country75 target enrollmentJanuary 2014

ConditionsPeriodontal Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Periodontal Disease
Sponsor: Polak David
Enrollment: 75
Locations: 1
Primary Endpoint: flow cytometry
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

aggressive periodontitis is an inflammatory disease which damage the teeth supporting structures mostly in young patients. and has genetic basis.

a specific bacteria: Aggregatibacter actinomycetemcomitans (Aa) is associated with this disease, and found to damage leukocytes by using a specific leukotoxin.

in the research the investigators are aiming to find molecular and immunological basis to aggressive periodontitis.

Registry

clinicaltrials.gov

Start Date

January 2014

End Date

October 2015

Last Updated

12 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Polak David

Responsible Party

Sponsor Investigator

Principal Investigator

Polak David

senior dentist, periodontology department

Hadassah Medical Organization

Eligibility Criteria

Inclusion Criteria

•patients in periodontal department
•diagnosed with chronic/aggressive periodontal disease
•interested in participating the research

Exclusion Criteria

•diagnosed with diabetes, heart disease, immunosuppression, thrombocytopenia, clotting enzyme deficiency.
•using alcohol, or drugs
•pregnancy

Outcomes

Primary Outcomes

flow cytometry

Time Frame: 12 hours after blood extraction

the investigators use flow cytometry technique in order to determine the influence of gingival bacteria on the leukocytes, after culturing the two together.