The Effect of In-vitro Myoinositol Supplementation of Human Sperm on the Outcome of Cryopreservation
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 41
- 主要终点
- Cryo-survival rate
研究概览
简要总结
The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.
详细描述
Sperm cryopreservation is considered the most valuable and used way to preserve male reproductive function. Unfortunately, osmotic effects of freezing and thawing during the cryopreservation process negatively affect sperm morphology and motility .
Myoinositol is the most biologically important form of inositol in nature. In male reproductive system, myoinositol appears to regulate sperm motility, capacitation and acrosomal reaction.
The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Infertile men with normal or abnormal semen analysis
排除标准
- •Azoospermic samples
研究组 & 干预措施
Normal S.A group
Infertile men with normal semen analysis. each sample is divided into 2 identical aliquots: one aliquot (Myo aliquot) is supplied with myoinositol, The other aliquot is left as it is (control aliquot).
干预措施: Myoinositol (Biological)
Abnormal S.A group
Infertile men with abnormal semen analysis. each sample is divided into 2 identical aliquots: one aliquot (Myo aliquot) is supplied with myoinositol, The other aliquot is left as it is (control aliquot).
干预措施: Myoinositol (Biological)
结局指标
主要结局
Cryo-survival rate
时间窗: 7 months
Post-thawing cryo-survival rates of both aliquots ( myo and control) are compared in both groups (A and B).
次要结局
未报告次要终点
研究者
Mohamed Alaa El-Dein Hasan
M.B.B.Ch.
Sohag University