Toxicity of Treatments for Non-tuberculous Mycobacterial Infections in Cancer Patients or Not

Recruiting

• Conditions: Cancer; Treatment Side Effects; Mycobacterium

• Registration Number: NCT05030701
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Non-tuberculous mycobacteria (NTM) are increasingly common and have a poor prognosis: 5-year mortality can reach 40 to 50%, depending on the type of mycobacteria and the immune system of the host involved. Cancer patients are at higher risk of infectious morbidity and mortality, which may be due to disease-related immune dysfunction, immunosuppressive effects of chemotherapy, or long-term placement of a vascular catheter. However, data on the treatment of NTM species that cause infections and the disease characteristics of these pathogens in cancer patients are limited despite the growing cancer population worldwide. Recently, M. avium infections have been described in patients suffering from cancers (hematological or not), in particular in patients receiving checkpoint inhibitors. Although the proportion of M. avium pneumonia in retrospective series is low (0.8-2%), it has been shown that this population is younger, suffers less from sub-pulmonary pathology. (indicating immunosuppression in these patients) but are therefore treated less than non-cancerous subjects.

This retrospective study in CHU Amiens is searching on the number of side effects of NTM treatment in two groups (cancerous and no cancerous) to assess the cause of the decrease of NTM treatment in cancerous patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-13
• Study First Submitted: 2021-07-13
• Study First Submitted QC: 2021-08-31
• Study First Posted: 2021-09-01
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-07
• Last Update Posted: 2023-02-08
• Primary Completion: 2023-10
• Study Completion: 2023-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• Age equal or more than 18 years18
• Patients diagnosed by an infection with non-tuberculous mycobacteria according to ATS guidelines.
• Patients received the NTM treatment.

Exclusion Criteria

• age less than 18 years
• Patients diagnosed by NTM without treatment.
• Patients with a positive sample of NTM but without infection.
• Exclusion of other disorders such as tuberculous.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
variation of side effects number of non-tuberculous mycobacteria treatment between cancerous and non cancerous patient groups.	3 months	The main objective of this study is to determine the number of side effects of the treatment of non-tuberculous mycobacteria in patients with this infection with or without cancer at the CHU Picardie Amiens.

Trial Locations

Locations (1)

CHU Amiens Picardie; 🇫🇷 Amiens, Picardie, France