GPI 15715 For Sedation in the Intensive Care Unit (ICU) Setting
- Conditions
- Respiration, ArtificialPostoperative SedationIntubation
- Registration Number
- NCT00125398
- Lead Sponsor
- Eisai Inc.
- Brief Summary
Patients who are in the intensive care unit after surgery and require mechanical breathing support (intubation and ventilation) usually require sedation to avoid agitation and excessive stress responses. Short-acting sedatives such as midazolam and propofol are the drugs typically used for this. Propofol provides for fast sedation and fast recovery from sedation. Midazolam is slower to sedation and slower for recovery, but may provide some advantages over propofol, such as a lower incidence of hypotension (low blood pressure). This study will look at propofol compared to a product with fast sedation and recovery like that of propofol but with less of a chance for hypotension like with midazolam. Patients will be treated with the product for up to 8 hours and then will be monitored for 8 hours following treatment.
- Detailed Description
Patients who are intubated and ventilated and will require up to 8 hours of sedation in the ICU are eligible for participation in this study. Patients will be randomized to receive 1 of 3 treatments. One treatment is standard of care, a propofol infusion. The other two treatment arms are infusions of GPI 15715 (AQUAVAN), one with a bolus and one without.
Patients will be treated for up to 8 hours and monitored for eight hours post treatment. If there are signs of agitation during the up to 8 hour treatment period, the infusion of the sedative medicine will be increased according to protocol.
Blood samples will be obtained periodically during the course of the study for safety evaluation and pharmacokinetic assessments. When the patient is ready for extubation or the end of the 8 hour study period has been reached, the infusion of the sedative agent will be discontinued and the patient will be monitored for 8 hours post treatment.
Guilford Pharmaceuticals was acquired by MGI PHARMA on October 3, 2005.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Require 2 to 8 hours of intubation and mechanical ventilation following elective surgery
- American Society of Anesthesiologists (ASA) status of I-IV
- Requires emergency agency
- Requires neuromuscular blockers during sedation
- Requires use of epidural drug administration during sedation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Safety and tolerability of infusions
- Secondary Outcome Measures
Name Time Method Determination of pharmacokinetic (PK) levels of GPI 15715 in blood Evaluation of the onset of effect Evaluation of satisfaction with sedation Percentage of patients requiring rescue medications
Trial Locations
- Locations (17)
Oklahoma University Medical Center
🇺🇸Oklahoma City, Oklahoma, United States
Mount Sinai School of Medicine
🇺🇸New York, New York, United States
Wake Forest University Baptist Medical Center
🇺🇸Winston-Salem, North Carolina, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
New York University School of Medicine
🇺🇸New York, New York, United States
Long Island Jewish Medical Center
🇺🇸New Hyde Park, New York, United States
University of Iowa Hospital and Clinics
🇺🇸Iowa City, Iowa, United States
Cooper University Hospital
🇺🇸Camden, New Jersey, United States
Jackson Memorial Hospital
🇺🇸Miami, Florida, United States
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Department of Veterans Affairs, North Texas Health Care System
🇺🇸Dallas, Texas, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Advocate Lutheran General Hospital
🇺🇸Park Ridge, Illinois, United States
St. Mary's Hospital
🇺🇸Rogers, Arizona, United States
Central Maine Pulmonary Associates
🇺🇸Auburn, Maine, United States
Montefiore Medical Center
🇺🇸Bronx, New York, United States