Correlation Between ΔPP/HR and ΔSV During Fluid Challenge.
- Conditions
- Hypovolemia
- Registration Number
- NCT02439242
- Lead Sponsor
- University Hospital, Caen
- Brief Summary
In high perioperative risk patients, guidelines suggest intraoperative haemodynamic optimization by measurement of stroke volume (SV) to guide fluid resucitation.This strategy requires an invasive monitoring and learning. Some studies tried to find SV surrogates based on haemodynamic usual parameters. In an experimental hemorrhagic shock, SV was correlated to the pulse pressure (PP) / heart rate (HR) ratio.
The investigators hypothesized that SV variations (ΔSV) would be correlated to the PP/HR ratio variations (ΔPP / HR) during fluid challenge, and ΔPP / HR would be able to detect a ΔSV greater than 10%.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- a suspected hypovolemia, based on clinical or paraclinical parameters.
- a fluid challenge decision at the discretion of the anaesthesiologist physician in charge of the patient.
Exclusion Criteria
- Minor or major patient under guardianship,
- oesophageal Diseases
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method correlation by linear regression between variations of the ratio PP/HR ( in percentage) and variations of SV ( in percentage) during fluid challenge 18 months
- Secondary Outcome Measures
Name Time Method Area under the receiver operating characteristic curve (AUC roc) of the ability of variations of the ratio PP/HR ( in percentage)during fluid challenge to predict an increase of SV greater than 10% 18 month
Trial Locations
- Locations (1)
CAEN University Hospital
🇫🇷Caen, Basse Normandie, France