NL-OMON48923
已完成
不适用
An fMRI and EEG study in patients with mild to moderate Alzheimer*s disease and healthy elderly controls - fMRI and EEG study in Alzheimer patients
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Alzheimer's Disease
- 发起方
- Centre for Human Drug Research
- 入组人数
- 24
- 状态
- 已完成
- 最后更新
- 去年
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •1\. Aged 50\- 80 years;
- •2\. Ability to communicate well with the investigator in the Dutch language;
- •3\. Willing to give written informed consent and to comply with the study
- •restrictions;
- •Additional inclusion criteria for the AD subjects are:
- •4\. Diagnosed with probable AD according to the National Institute of
- •Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease
- •and Related Disorders Association (NINCDS\-ADRDA) criteria confirmed by the
- •treating physician;
- •5\. MMSE score 18\-26 (inclusive);
排除标准
- •1\. Any contra\-indications for MRI (prostheses, implants, claustrophobia,
- •pacemakers, etc.);
- •2\. Presence or history of alcohol abuse, or daily alcohol consumption exceeding
- •2 standard drinks per day on average for females or exceeding 3 standard drinks
- •per day on average for males (1 standard drink \= 10 grams of alcohol), or a
- •positive breath alcohol test at screening or upon admission to the Clinical
- •Research Unit (CRU);
- •3\. Use of tobacco and/or nicotine\-containing products within 30 days of day 1;
- •4\. Positive urine drug screen at screening or day 1;
- •5\. Unable to refrain from use of (methyl) xanthine (e.g. coffee, tea, cola,
结局指标
主要结局
未指定
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