ACTRN12613001114730
Completed
N/A
A study on the effects of noninvasive ventilation used as weaning strategy on duration of invasive mechanical ventilation when compared to a conventional weaning approach with endotracheal tube in place in patients with hypoxemic acute respiratory failure.
avalesi Paolo0 sites130 target enrollmentOctober 4, 2013
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Weaning in Hypoxemic Acute Respiratory Failure
- Sponsor
- avalesi Paolo
- Enrollment
- 130
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Invasive mechanical ventilation duration \> 48 hours; PaO2/FiO2 ranging between 200 and 300 with a positive end\-expiratory pressure PEEP \> 8 and \< \= 12 cmH2O and a FiO2 \<\= 0\.6; Pressure Support Ventilation (PSV) with a total applied pressure (i.e. PEEP \+ inspiratory support) \<\= 25 cmH2O; PaCO2 \<\= 50 mmHg; pH \>\= 7\.35; Respiratory rate (RR) \<\= 30/min; Core body temperature \<\= 38\.5 (degrees celsius); Glasgow Coma Scale (GCS) \>\= 10; Presence of clearly audible cough during suctioning; Tracheal suctioning\<\= 2/hr
Exclusion Criteria
- •Severe hemodynamic instability as assessed: a) systolic arterial pressure \< 90 mmHg, despite adequate filling, b) need for continuous infusion of epinephrine, norepinephrine or vasopressine, c) need for dopamine or dobutamine \> 5microg/Kg/min
- •Life\-threatening arrhythmias or ECG signs of ischemia; Severe sepsis or septic shock;
- •ARF secondary to congestive heart failure, neurological disorders, status asmaticus, chronic obstructive pulmonary disease; Tracheotomy; Copious secretions or uncontrolled vomiting; Spinal cord injury or neuro\-muscular disorder; Presence of 2 or more criteria of organ failure; Body mass index \>\= 30; Obstructive sleep apnea syndrome
Outcomes
Primary Outcomes
Not specified
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