Brain Activity During Jaw Tapping Movement in Healthy Subjects and Mild Cognitive Impairment Patients Using Functional Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Brain activity of n-back task
研究概览
简要总结
The purpose of this study is to examine the possibility of using jaw-tapping training as a self-exercise for developing memory and preventing dementia in elderly subjects with memory disturbances using functional magnetic resonance imaging (fMRI).
详细描述
Right-handed female volunteers over the age of 50 years with subjective memory complaints are included in the study. Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders are excluded.
The protocol was approved by the Institutional Review Board of university-based hospital.
After administering the Seoul Neuropsychological Screening Battery (SNSB), Mini-Mental State Examination (MMSE) scores above 24 and Clinical Dementia Rating Scale (CDR) scores of 0 are considered subjective memory complaints (SMC), and MMSE scores above 23 and CDR scores of 0.5 are considered MCI.
All subjects undergo two MRI scans. After the first MRI, the subjects are trained to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Right-handed female volunteers over the age of 50 years with subjective memory complaints
排除标准
- •Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders
研究组 & 干预措施
Jaw tapping
All subjects performed the jaw-tapping for 4 weeks at home.
干预措施: Jaw-tapping (Behavioral)
结局指标
主要结局
Brain activity of n-back task
时间窗: up to 4 weeks
All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home. Pre- and post-test fMRI data during the n-back task are analyzed using statistical parametric maps of brain activation.
次要结局
- Brain activity of jaw-tapping task(baseline and 4 weeks)
研究者
Seung-Yeon Cho
fellow, Kyung Hee University Hospital at Gangdong
Kyunghee University Medical Center