Functional Magnetic Resonance Imaging Study of Jaw-tapping Movement on Memory Function

Not Applicable

• Conditions: Memory Disturbances
• Interventions: Behavioral: Jaw-tapping

• Registration Number: NCT01873664
• Lead Sponsor: Kyunghee University Medical Center

Brief Summary

The purpose of this study is to examine the possibility of using jaw-tapping training as a self-exercise for developing memory and preventing dementia in elderly subjects with memory disturbances using functional magnetic resonance imaging (fMRI).

Detailed Description

Right-handed female volunteers over the age of 50 years with subjective memory complaints are included in the study. Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders are excluded.

The protocol was approved by the Institutional Review Board of university-based hospital.

After administering the Seoul Neuropsychological Screening Battery (SNSB), Mini-Mental State Examination (MMSE) scores above 24 and Clinical Dementia Rating Scale (CDR) scores of 0 are considered subjective memory complaints (SMC), and MMSE scores above 23 and CDR scores of 0.5 are considered MCI.

All subjects undergo two MRI scans. After the first MRI, the subjects are trained to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.

Study Timeline

• Study Start: 2009-05
• Status Verified: 2013-06
• Study First Submitted: 2013-06-03
• Study First Submitted QC: 2013-06-07
• Last Update Submitted: 2013-06-07
• Study First Posted: 2013-06-10
• Last Update Posted: 2013-06-10
• Primary Completion: 2013-07
• Study Completion: 2013-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• Right-handed female volunteers over the age of 50 years with subjective memory complaints

Exclusion Criteria

• Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Jaw tapping	Jaw-tapping	All subjects performed the jaw-tapping for 4 weeks at home.

Primary Outcome Measures

Name	Time	Method
Brain activity of n-back task	up to 4 weeks	All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home.; Pre- and post-test fMRI data during the n-back task are analyzed using statistical parametric maps of brain activation.

Secondary Outcome Measures

Name	Time	Method
Brain activity of jaw-tapping task	baseline and 4 weeks	All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home.; Pre- and post-test fMRI data during the jaw-tapping task are analyzed using statistical parametric maps of brain activation.

Trial Locations

Locations (1)

Kyung Hee University Hospital at Gangdong; 🇰🇷 Seoul, Korea, Republic of