Mnemic neglect in dementia

Not Applicable

Completed

• Conditions: Topic: Dementias and neurodegeneration; Subtopic: Dementia; Disease: Dementia; Nervous System Diseases

• Registration Number: ISRCTN30485698
• Lead Sponsor: niversity of the West of England, Bristol

Brief Summary

2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29797355 results 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/30734372/ (added 09/02/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-01-12
• Study Completion: 2016-10-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

1. A diagnosis made within the previous 18 months by a consultant psychiatrist of either probable Alzheimer’s disease according to the NINCDS-ADRDA criteria (McKhann et al, 1984) or probable vascular dementia according to the NINDS-­IREN criteria (Román et al, 1993) or a mixed form of these
2. Mild levels of cognitive impairment (e.g. MOCA score over 12 or equivalent score on an alternative assessment tool)
3. The capacity to consent to be part of the research
4. Sufficient communication skills to be able to take part in the research

Control group:
Healthy volunteers recruited from Join Dementia Research (JDR) register, students and staff at the University of the West of England

Exclusion Criteria

1. They have a significant history of pre-­morbid psychiatric problems
2. They have a diagnosis of dementia with Lewy Bodies (McKeith, 2002) or frontal­-temporal dementia (Snowden, Neary and Mann (2002)
3. If deficits in short-­term memory are not a primary cause of disability

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Current primary outcome measures as of 11/01/2017:<br> Study A: the mean number of dementia and non-dementia words recalled<br> Study B: the mean number of behaviour statements recalled (central or peripheral and positive or negative)<br> Study C: the mean number of high threat and low threat dementia statements recalled<br> There was only one timepoint to this study, the research appointment lasted up to an hour and the method was to simply count up the number of correct words/behaviours/statements recalled or recognised by each participant<br><br> Previous primary outcome measures:<br> Number of words, statements, descriptions recalled:<br> 1. Straight after presentation<br> 2. After a 2 minute delay<br>

Secondary Outcome Measures

Name	Time	Method
<br> Current secondary outcome measures as of 11/01/2017:<br> All three studies: recognition scores and intrusion errors<br> There was only one timepoint to this study, the research appointment lasted up to an hour and method was to simply count up the number of correct words/behaviours/statements recalled or recognised by each participant<br><br> Previous secondary outcome measures:<br> Recognition of words, statements and descriptions after recall tasks:<br> 1. Straight after presentation<br> 2. After a 2 minute delay<br>