Long-term Follow-up Near-infrared Spectroscopy and Intravascular Ultrasound Imaging of Internal Carotid Artery Stenosis Treated With Stenting
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Carotid Atherosclerosis
- Sponsor
- University Hospital, Motol
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Temporal change of lipid core burden index (LCBI)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The 'Long-term Follow-up Near-infrared Spectroscopy and Intravascular Ultrasound Imaging of Internal Carotid Artery Stenosis Treated With Stenting' trial is an academic research project. It follows already published results of a research on carotid plaque composition in patients undergoing carotid stenting.
Patients who were treated with carotid stenting will be invited to participate on the trial. The written informed consent will be needed. The participants will undergo carotid angiography, intravascular near-infrared spectroscopy and intravascular ultrasound of the extracranial portion of the internal and common carotid artery with implanted stent.
The aim of the trial is to describe long-term change of the luminal and stent dimensions, vessel wall remodeling and plaque composition after carotid stenting. The findings will help to understand the long-term effect of carotid stenting on the carotid stenosis and mechanisms of plaque stabilization - sealing with stent.
Investigators
Cyril štěchovský
Principal Investigator
University Hospital, Motol
Eligibility Criteria
Inclusion Criteria
- •previous carotid stenting
- •data from periprocedural NIRS-IVUS available
- •written informed consent
Exclusion Criteria
- •occlusion of the carotid artery on the side of the implanted stent
- •indication for carotid intervention on the side of the implanted stent
- •high procedural risk (difficult anatomy, risk of puncture site bleeding)
Outcomes
Primary Outcomes
Temporal change of lipid core burden index (LCBI)
Time Frame: 16 months
Difference between LCBI (a dimensionless number) within the segment of the carotid artery with implanted stent in the time point of the carotid stenting (baseline LCBI) and in the time point of study intervention (follow-up LCBI). Data from NIRS.
Secondary Outcomes
- Late lumen change(16 months)
- Late stent expansion(16 months)