Reversing malnutrition with targeted enteral feeding in patients awaiting liver transplantation: a randomized controlled trial

Not Applicable

Completed

• Conditions: iver disease; Malnutrition; Liver transplant; Sarcopenia; Liver disease; Diet and Nutrition - Other diet and nutrition disorders; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12618000666224
• Lead Sponsor: Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-04-24
• Study Completion: 2023-05-20
• Last Update Posted: 16 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

All adult patients activated onto the liver transplant waiting list with:
-Diagnosis of severe malnutrition (SGA C)
-Handgrip strength below the sarcopenia cut-off for their age/sex
-Functional gastrointestinal tract
-MELD score >16

Exclusion Criteria

Participants on the liver transplant waiting list will be excluded if they:
-Are well nourished (SGA A) or mild-moderately malnourished (SGA B)
-Are not sarcopenic as per handgrip strength cut off
-Without functioning gastrointestinal tract
-Have a low severity of liver disease (MELD <16)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in handgrip strength prior to liver transplant, as measured by handgrip dynamometry.[ Baseline, 2 weeks, 4 weeks (primary endpoint) after enrolment, then every 4 weeks thereafter until liver transplant<br>]