Efficacy of Hyalase Hydro-dissection in Treatment of Carpal Tunnel: Randomized Double Blind Controlled Clinical Trial
Overview
- Phase
- Not Applicable
- Intervention
- Hyalase
- Conditions
- Carpal Tunnel Syndrome
- Sponsor
- Assiut University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- pain alleviation
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy, this study aims to investigate if, and to what extent hydro-dissection hyalase and saline of the median nerve could offer symptoms and clinical improvement
Detailed Description
Carpal tunnel syndrome (CTS) is the most common compression syndrome the upper extremities. Its problem has a high prevalence ranged estimated prevalence of 3.8% in the general population, 3 and 7.8% in the working population. It occurs at any age, especially in individuals in their 40s to 60s, and the male: female ratio is reported to be 3:7. A lot of treatment modalities have been tried to improve the condition, starting from local anesthetic injection, steroid, and up to surgical decompression of the nerves.
Investigators
Emad Zarief , MD
Associate professor of Anesthesia, ICU, and pain
Assiut University
Eligibility Criteria
Inclusion Criteria
- •adult patients
- •complaining of carpal tunnel syndrome of 3 month duration or more
- •diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study
Exclusion Criteria
- •patient refusal
- •infection at the site of intervention
- •local anesthetic allergy
Arms & Interventions
Comparator: Hyalase
injection of Hyalase + 10 cc saline injection nearby median nerve as hydro-dissection
Intervention: Hyalase
Saline
Injection 10 cc saline injection as a median nerve hydro-dissection
Intervention: Saline
Outcomes
Primary Outcomes
pain alleviation
Time Frame: 6 months
visual analog scale of pain value of (0 cm) no pain , and value of (10 cm) worst pain
Secondary Outcomes
- Changes in ultrasound imaging(6 months)
- Changes in median nerve conduction parameters(6 months)