ISRCTN01000893
Completed
未知
Effect of pregabalin in acute post-operative pain and functional recovery for laparoscopic cholecystectomy
Pfizer (Canada)0 sites162 target enrollmentFebruary 13, 2007
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Pfizer (Canada)
- Enrollment
- 162
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
2010 results in https://doi.org/10.1093/bja/aeq116 (added 26/03/2021)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Patients 18 to 65 years of age undergoing cholecystectomy under general anesthesia
- •2\. Able to tolerate standard medications \- 1000 mg of acetaminophen and 500 mg of naproxen
Exclusion Criteria
- •1\. Clinically diagnosed acute pancreatitis requiring urgent cholecystectomy
- •2\. Allergy to gabapentin or pregabalin
- •3\. Allergy to Non\-Steroidal Anti\-Inflammatory Drugs (NSAID) or acetaminophen
- •4\. No analgesic within 24 hours before surgery (other than premedication)
- •5\. Patients with Body Mass Index (BMI) more than 40
- •6\. Serious organ disease
- •7\. Creatinine clearance less than or equal to 60 mL
- •8\. Chronic pain patients requiring more than 30 mg morphine per day or equivalent
- •9\. Severe psychiatric disease
- •10\. Drug addiction
Outcomes
Primary Outcomes
Not specified
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