EyeConic: Qualification for Cone-Optogenetics

Recruiting

• Conditions: Retinal Dystrophies
• Interventions: Diagnostic Test: Optical coherence tomography (OCT)

• Registration Number: NCT05294978
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.

Detailed Description

In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them through targeted optogenetic tools. However, the true proportion of low vision patients harboring dormant, non-functional cones, is currently unknown. The worldwide multicenter retrospective study (EyeConic) aims to estimate the proportion of low vision patients with remaining cone cell bodies for the first time.

Study Timeline

• Study Start: 2021-07-01
• Study First Submitted: 2022-02-16
• Study First Submitted QC: 2022-03-14
• Study First Posted: 2022-03-24
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-06
• Last Update Posted: 2025-02-07
• Primary Completion: 2026-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients	Optical coherence tomography (OCT)	-Availability of macular optical coherence tomography (OCT)
Controls	Optical coherence tomography (OCT)	-Availability of macular optical coherence tomography (OCT)

Primary Outcome Measures

Name	Time	Method
OCT - Central retinal volume	Baseline (about 10 minutes)	Number of participants with preserved central retinal volume

Trial Locations

Locations (9)

University of California San Francisco, Department of Ophthalmology; 🇺🇸 San Francisco, California, United States

Bascom Palmer Eye Institute; 🇺🇸 Miami, Florida, United States

University of Pittsburgh, Department of Ophthalmology; 🇺🇸 Pittsburgh, Pennsylvania, United States

Beijing Institute of Ophthalmology; 🇨🇳 Beijing, China

Universitätsklinikum Tübingen Augenklinik; 🇩🇪 Tübingen, Germany

Semmelweis University, Department of Ophthalmology; 🇭🇺 Budapest, Hungary

Oculista Ospedale Parma; 🇮🇹 Parma, Italy

University Hospital Basel, Eye Clinic; 🇨🇭 Basel, Switzerland

Moorfields Eye Hospital; 🇬🇧 London, United Kingdom