Comparison of clinical effectiveness between average volume assured pressure support (AVAPS) with BiPAP S/T in chronic obstructive pulmonary disease with acute exacerbation: a randomized clinical trial

Phase 1

Recruiting

• Conditions: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD); Chronic obstructive pulmonary disease; None invasive ventilation; AECOPD; Exacerbation; NIV; None invasive positive pressure ventilation; NIPPV; BiPAP S/T; Average Volume Assured Pressure Support

• Registration Number: TCTR20180903004
• Lead Sponsor: Siriraj Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-09-03
• Study Completion: 2018-10-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

1.Age >,= 18 years old
2.Patients with COPD presented with respiratory distress meeting at least one of the following criteria
-Pulse oximetry < 90% when breathing at room air
-Signs of respiratory distress e.g. accessory muscle use
-Respiratory rate ≥ 30 breaths/min
-ABG show acute respiratory acidosis determined by ED physician

Exclusion Criteria

1.Refusal of treatment
2.Agitation or non-cooperation
3.Facial deformity
4.Obstruction in the upper airway from surgery or trauma
5.Alterations of the central nervous system not related to hypercapnic encephalopathy (GCS <9)
6.Cardiogenic pulmonary edema
7.Pneumothorax
8.Pulmonary thromboembolism
9.Hemoptysis or septic shock
10.Emergency intubation due to acute respiratory failure or cardiopulmonary arrest
11.Hemodynamic instability with systolic pressure below 90 mmHg

Study & Design

• Study Type: Interventional
• Study Design: Not specified