3D Printed Bolus in Post-mastectomy Radiotherapy

Not Applicable

• Conditions: Breast Neoplasms; Radiotherapy Side Effect
• Interventions: Other: customized 3D-printed bolus fabricated based on reconstruction of computed tomography (CT) images

• Registration Number: NCT04685460
• Lead Sponsor: Jiangxi Provincial Cancer Hospital

Brief Summary

Recently, there is growing interest in the application of three-dimensional (3D) printed bolus to radiotherapy.At present, the researches on the application of 3D-printed bolus in breast cancer are mainly focused on air gap between skin and bolus or electron beam conformal therapy \[7,15\], there are no clinical experience with customized 3D-printed bolus for volumetric modulated arc therapy (VMAT) in daily practice has been published up to now. We aim to evaluate dosimetry and application of 3D-printed bolus for the post-mastectomy radiotherapy (PMRT) with Volumetric modulated arc therapy (VMAT). Seventy five patients with breast cancer receiving radiotherapy following post-mastectomy in our department were randomly selected in this study. The accuracy of fit of the 3D-Printed bolus to the chest wall was improved significantly relative to conventional bolus.This study demonstrates customized 3D-printed bolus in post-mastectomy radiation therapy improves fit of the bolus compared to conventional bolus. Furthermore, VMAT based on 3D-printed bolus significantly improves the chest wall target coverage and the conformity of plan, and reduces the dose of ipsilateral lung and heart, compared to conventional bolus.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-01
• Status Verified: 2020-11
• Study First Submitted: 2020-11-18
• Study First Submitted QC: 2020-12-21
• Study First Posted: 2020-12-28
• Last Update Submitted: 2021-04-14
• Primary Completion: 2021-04-15
• Last Update Posted: 2021-04-19
• Study Completion: 2021-04-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• breast cancer patients with post-mastectomy treatment

Exclusion Criteria

• NA

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
3D-printed bolus	customized 3D-printed bolus fabricated based on reconstruction of computed tomography (CT) images	-

Primary Outcome Measures

Name	Time	Method
dose comparison	one year	The prescription dose was 50 Gy in 25 fractions. Dose-volume histograms (DVHs) were used dosimetric analysis. D98%, D50% and D2%, indicating dose to 98% (near-minimum dose), 50% and 2% (near-maximum dose) of both target volumes, and V95%, V100%, and V110% indicating percent volume receiving 95%, 100% and 110% of prescribed dose, were recorded

Trial Locations

Locations (1)

Jiangxi Cancer Hospital of Nanchang University; 🇨🇳 Nanchang, Jiangxi, China