Venous Congestion and Organ Dysfunction in Intensive Care: a Prospective, Multicenter, Observational Study to Evaluate Prevalence and Risk Factors.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 185
- 试验地点
- 1
- 主要终点
- the presence of venous congestion
研究概览
简要总结
Venous congestion, which is a phenomenon described in cardiology and post-operative cardiac surgery, is responsible for an increase in morbidity and mortality.
Indeed, it can lead to kidney failure, liver failure, prolonged ileus, scarring complications, and neurological disorders. Clinical and ultrasound indications have been described to diagnose this condition.
To date, this phenomenon is poorly known and not described in intensive care patients outside the cardiac context. However, intensive care patients can present the risk factors associated with the occurrence of congestion: acute cardiac failure, significant water-salt overload, and/or fluid distribution anomalies. Thus, observational studies have found an association between the input-output balance, the quantity of salt-water intake, the presence of right heart dysfunction and the occurrence of acute kidney failure, digestive disorders, hypoxemia and a prolonged stay in intensive care. The presence of a congestive condition is medically treatable since diuretic decongestion is associated with improved cardiac outcomes.
It is therefore necessary, in an intensive care context, to be able to define and diagnose this state of venous congestion, to study its prevalence, and to confirm the existence of a link with organ failure in order to pave the way to known adapted treatment options.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient who has expressed his or her non-opposition to the collection of data (or the health care proxy, or a close relative if the patien is unable to receive the information)
- •Patient admitted to intensive care for less than 24 hours.
排除标准
- •Person not affiliated to the national health insurance
- •Minor, protected major
- •Pregnant or breastfeeding women
- •Anechogenicity confirmed by the operator
- •Chronic atrial fibrillation
- •Mechanical cardiac assistance
- •Uncontrolled blood pressure (MAP < 65 mmHg)
研究组 & 干预措施
patient
Patient admitted to intensive care for less than 24 hours.
干预措施: collection of biological parameters (Other)
patient
Patient admitted to intensive care for less than 24 hours.
干预措施: collection of echographic parameters (Other)
patient
Patient admitted to intensive care for less than 24 hours.
干预措施: collection of clinical parameters (Other)
结局指标
主要结局
the presence of venous congestion
时间窗: From date of inclusion until the date of discharge from hospital or date of death from any cause, whichever came first, assessed up to 28 day
次要结局
未报告次要终点
