Effects of acute hydroxy gas inhalation on exercise-induced bronchoconstrictio
Not Applicable
- Conditions
- Exercise-induced bronchoconstrictionRespiratory
- Registration Number
- ISRCTN11644788
- Lead Sponsor
- niversity of Kent
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
1. Ability to consent to the research
2. Aged 18 to 50 years old
3. Current clinical-based diagnosis of exercise-induced bronchoconstriction
4. Normal resting forced expiratory volume in one second (FEV1) defined as greater than 80% predicted value
Exclusion Criteria
1. Chest infection within the past 4 weeks or hospitalisation
2. Baseline FEV1 <80% predicted value
3. Any other respiratory condition (other than asthma)
4. Any other chronic medical conditions (e.g., cardiovascular, neurological and metabolic)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Eucapnic Voluntary Hyperpnoea (EVH) challenge with lung function measures taken in triplicate before and in duplicate at 3, 5, 7, 10 and 15 minutes post EVH challenge.<br> 2. Urinary 9a,11ß-prostaglandin and Clara cell protein (CC16) levels measured using enzyme-linked immunosorbent assay (ELISA) of samples collected before and after (~1 h) EVH challenge<br> 3. Blood hydroxyl radical levels measured using a blood test in samples before and after (~1 h) EVH challenge<br>
- Secondary Outcome Measures
Name Time Method Difficulty breathing measured using the revised Borg Rating of Perceived Exertion (RPE) scale at baseline and immediately following the EVH challenge