The Effects Of Remote Organ Ischemic Preconditioning On Systemic Inflammatory And Glycocalyx Integrity Parameters In Living-Donor Liver Transplantation Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Intercellular adhesion molecule-1 (ICAM-1)
研究概览
简要总结
Ischemia-reperfusion (IR) injury during liver transplantation is one of the major causes of mortality and morbidity associated with transplantation. Remote organ ischemic preconditioning (RIPC) is one of the most investigated practices to reduce IR injury. In this study, for the first time in the clinic, the effect of RIPC will be evaluated via both systemic inflammation parameters and also parameters showing glycocalyx integrity, on living-donor liver recipients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients followed up by Acıbadem Hospital Organ Transplantation Center
- •Patients accepted to participate in the study
- •Older than 18 years of age
- •ASA class III
- •MELD score >12
- •Scheduled for elective liver transplantation surgery from a living donor
排除标准
- •Patients undergoing re-transplantation
- •Under the age of 18 years
- •Patients undergoing emergency surgery
- •Patients with hepatorenal or hepatopulmonary syndrome
- •Patients receiving mechanical ventilation support in the ICU
- •Patients refusing to participate
结局指标
主要结局
Intercellular adhesion molecule-1 (ICAM-1)
时间窗: Postoperative early period (6 hours after intensive care unite admission)
Evaluation of (ICAM-1) level difference between group
Syndecan-1 (SDC-1)
时间窗: Postoperative early period (6 hours after intensive care unite admission)
Evaluation of SDC-1 level difference between groups
Tumor necrosis factor-alpha (TNF-alpha)
时间窗: Postoperative early period (6 hours after intensive care unite admission)
Evaluation of TNF-alpha level difference between groups
Hypoxia-induced factor-1 (HIF-1)
时间窗: Postoperative early period (6 hours after intensive care unite admission)
Evaluation of HIF-1 level difference between groups
Interleukin-8 (IL-8)
时间窗: Postoperative early period (6 hours after intensive care unite admission)
Evaluation of IL-8 level difference between groups
soluble Vascular cell adhesion molecule-1 (sVCAM-1).
时间窗: Postoperative early period (6 hours after intensive care unite admission)
Evaluation of sVCAM-1 level difference between groups
次要结局
- Liver function tests(7 days after surgery)
- Length of stay in hospital and intensive care unit(7 days after surgery)
- Morbidity(7 days after surgery)
- Mortality(7 days after surgery)