To check and compare the effect of papaya gel for the treatment of gum conditions

Phase 2/3

Completed

Conditions: Chronic periodontitis,

Registration Number: CTRI/2019/12/022201

Lead Sponsor: Dr Abhilasha Jha

Brief Summary: Herbal extracts derived from medicinal plants aregaining wide popularity for the treatment of various diseases. This isprimarily due to the least amount of toxicity that they exhibit along withbeing economical.

One such medicinal plant is *Carica papaya* or the pawpaw plant popularly cultivated in thetropical belt of South-East Asia. Its properties have beenestablished and largely studied in medicine. However, it still is greatlyunexplored in the field of dentistry.

The aim of this study was to assess and compare the effect of Papaya (*Carica papaya*) raw fruit and leafextract on the clinical signs and symptoms of Chronic Periodontitis.

The results analysed through the pilotstudy revealed that C. papaya plant extracts have a definite anti-microbialactivity against the periodontal pathogens namely *P. intermedia*, *P. gingivalis*and *A. actinomycetemcomitans* under laboratory conditions*.* Based on these evaluations, this studywas conducted to compare and assess its effect on the clinical signs andsymptoms of Chronic Periodontitis. The results derived from this study conclude that the aqueousextracts of the epicarp of raw fruit and leaf of papaya plant used as anadjunct to Scaling and Root Planing(SRP) have superior effect in the treatment of Chronic Periodontitisas compared to SRP alone. It also concluded that there is no statisticaldifference between the results observed of leaf and raw fruit on Day 45.However, the intra-group differences between the two Sites A and B on Day 7 and45 suggest that the leaf extract has a superior effect as compared to theepicarp of raw fruit extract. This maybe attributed to the increased presence of papain and chymopapain enzymes inthe leaf as compared to the epicarp of raw fruit of the plant.

Further research should be conducted to understandthe factors behind these properties observed in C. papaya plant. It should alsobe studied in a larger population for a longer duration of time. This studyconcludes that the herbal extracts of papaya plant can be used as an adjunct toSRP for the treatment of Chronic Periodontitis. It helps in paving an alternatepath through the local drug delivery systems.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 20

Inclusion Criteria

Moderate chronic periodontitis, Probing Pocket Depth of 5-7mm, Clinical attachment loss of >3mm.

Exclusion Criteria

Systemically compromised, tobacco consumers, pregnant and lactating mothers, antibiotic usage in the past six months.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction of clinical symptoms of chronic periodontitis by checking probing pocket depth, clinical attachment loss, gingival index and bleeding index	Over a period of 45 days

Secondary Outcome Measures

Name	Time	Method
Adverse drug reaction if any	Over a period of 45 days

Trial Locations

Locations (1): Maratha Mandal s N.G.H Institute of Dental Sciences and Research Center
🇮🇳
Belgaum, KARNATAKA, India
Maratha Mandal s N.G.H Institute of Dental Sciences and Research Center
🇮🇳Belgaum, KARNATAKA, India
Dr Abhilasha Jha
Principal investigator
9611725715
dr.abhilashajha@gmail.com